Differentiation of ICM Cells into Trophectoderm

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1988 Aug 1

PMID 3400778

Citations 5

Authors

G B Pierce

J Arechaga

C Muro

R S Wells

Affiliations

Soon will be listed here.

Abstract

It has been established previously that when inserted in the blastocyst E Ca 247 preferentially differentiates into trophectoderm in vitro. If the concept that tumors are caricatures of the process of tissue renewal is correct, then some cells from the inner cell mass (ICM), the normal counterpart of embryonal carcinoma, should be able to differentiate into trophectoderm. This has been a controversial issue. Four experiments are now reported that support the idea that ICM can differentiate into trophectoderm: 1) ICM from early blastocysts after classical immunosurgery made blastocysts in vitro; 2) ICM obtained from early blastocysts by immunosurgery using antigens other than histocompatibility ones made blastocysts in vitro; 3) ICM from early blastocysts, in which the trophectodermal cells had been labeled, contained no labeled cells following immunosurgery; and 4) In reconstruction experiments, polar and mural trophectodermal cells attached to ICM from late blastocysts failed to multiply and make blastocysts when cultured. It is concluded that like the embryonal carcinoma some ICM cells of early blastocysts have the potential to make trophectoderm. This fact is consistent with the concept that tumors are caricatures of the process of tissue renewal; and establishes E Ca 247 as a good model for study of trophectodermal differentiation.

Citing Articles

A chemically defined system supports two distinct types of stem cell from a single blastocyst and their self-assembly to generate blastoid.

Wu B, Yang Z, Liu Y, Li J, Chen C, Li X Cell Prolif. 2023; 56(6):e13396.

PMID: 36593753 PMC: 10280139. DOI: 10.1111/cpr.13396.

Trophectoderm regeneration to support full-term development in the inner cell mass isolated from bovine blastocyst.

Kohri N, Akizawa H, Iisaka S, Bai H, Yanagawa Y, Takahashi M J Biol Chem. 2019; 294(50):19209-19223.

PMID: 31704705 PMC: 6916479. DOI: 10.1074/jbc.RA119.010746.

Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway.

Wigger M, Kisielewska K, Filimonow K, Plusa B, Maleszewski M, Suwinska A Sci Rep. 2017; 7(1):15136.

PMID: 29123210 PMC: 5680175. DOI: 10.1038/s41598-017-15427-0.

Epigenetic Interactions and Gene Expression in Peri-Implantation Mouse Embryo Development.

Latimer J, Pedersen R Mod Cell Biol. 2016; 12:131-171.

PMID: 26855474 PMC: 4742352.

Mechanism of programmed cell death in the blastocyst.

Pierce G, Lewellyn A, Parchment R Proc Natl Acad Sci U S A. 1989; 86(10):3654-8.

PMID: 2726743 PMC: 287196. DOI: 10.1073/pnas.86.10.3654.

References

Rossant J . Investigation of the determinative state of the mouse inner cell mass. I. Aggregation of isolated inner cell masses with morulae. J Embryol Exp Morphol. 1975; 33(4):979-90. View

Cox Jr W, Pierce G . The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat. Cancer. 1982; 50(8):1530-8. DOI: 10.1002/1097-0142(19821015)50:8<1530::aid-cncr2820500813>3.0.co;2-9. View

Pierce G, Lewis S, Miller G, Moritz E, Miller P . Tumorigenicity of embryonal carcinoma as an assay to study control of malignancy by the murine blastocyst. Proc Natl Acad Sci U S A. 1979; 76(12):6649-51. PMC: 411925. DOI: 10.1073/pnas.76.12.6649. View

Rizzino A, Bowen-Pope D . Production of PDGF-like growth factors by embryonal carcinoma cells and binding of PDGF to their endoderm-like differentiated cells. Dev Biol. 1985; 110(1):15-22. DOI: 10.1016/0012-1606(85)90058-2. View

Pierce G, Arechaga J, Jones A, Lewellyn A, Wells R . The fate of embryonal-carcinoma cells in mouse blastocysts. Differentiation. 1987; 33(3):247-53. DOI: 10.1111/j.1432-0436.1987.tb01564.x. View

Rossant J . Investigation of the determinative state of the mouse inner cell mass. II. The fate of isolated inner cell masses transferred to the oviduct. J Embryol Exp Morphol. 1975; 33(4):991-1001. View

Rizzino A . Early mouse embryos produce and release factors with transforming growth factor activity. In Vitro Cell Dev Biol. 1985; 21(9):531-6. DOI: 10.1007/BF02620847. View

Hillman N, Tasca R . Ultrastructural and autoradiographic studies of mouse cleavage stages. Am J Anat. 1969; 126(2):151-73. DOI: 10.1002/aja.1001260203. View

Evans M, Kaufman M . Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981; 292(5819):154-6. DOI: 10.1038/292154a0. View

10.

Calarco P, Brown E . An ultrastructural and cytological study of preimplantation development of the mouse. J Exp Zool. 1969; 171(3):253-83. DOI: 10.1002/jez.1401710303. View

11.

Pierce G . The cancer cell and its control by the embryo. Rous-Whipple Award lecture. Am J Pathol. 1983; 113(1):117-24. PMC: 1916304. View

12.

Papaioannou V, McBurney M, Gardner R, Evans M . Fate of teratocarcinoma cells injected into early mouse embryos. Nature. 1975; 258(5530):70-73. DOI: 10.1038/258070a0. View

13.

Pierce G . Teratocarcinoma: model for a developmental concept of cancer. Curr Top Dev Biol. 1967; 2:223-46. DOI: 10.1016/s0070-2153(08)60289-6. View

14.

Gardner R, Johnson M . Investigation of cellular interaction and deployment in the early mammalian embryo using interspecific chimaeras between the rat and mouse. Ciba Found Symp. 1975; 0(29):183-200. DOI: 10.1002/9780470720110.ch9. View

15.

Solter D, Knowles B . Immunosurgery of mouse blastocyst. Proc Natl Acad Sci U S A. 1975; 72(12):5099-102. PMC: 388883. DOI: 10.1073/pnas.72.12.5099. View

16.

TARKOWSKI A, Wroblewska J . Development of blastomeres of mouse eggs isolated at the 4- and 8-cell stage. J Embryol Exp Morphol. 1967; 18(1):155-80. View

17.

Nadijcka M, Hillman N . Ultrastructural studies of the mouse blastocyst substages. J Embryol Exp Morphol. 1974; 32(3):675-95. View

18.

Harlow G, Quinn P . Isolation of inner cell masses from mouse blastocysts by immunosurgery or exposure to the calcium ionophore A23187. Aust J Biol Sci. 1979; 32(4-5):483-91. DOI: 10.1071/bi9790483. View

19.

Hillman N, Sherman M, Graham C . The effect of spatial arrangement on cell determination during mouse development. J Embryol Exp Morphol. 1972; 28(2):263-78. View

20.

Hogan B, Tilly R . In vitro development of inner cell masses isolated immunosurgically from mouse blastocysts. I. Inner cell masses from 3.5-day p.c. blastocysts incubated for 24 h before immunosurgery. J Embryol Exp Morphol. 1978; 45:93-105. View