BMP Signaling Alters Aquaporin-4 Expression in the Mouse Cerebral Cortex

Overview

Journal Sci Rep

Specialty Science

Date 2021 May 19

PMID 34006980

Citations 3

Authors

Kazuya Morita

Naoyuki Matsumoto

Kengo Saito

Toshihide Hamabe-Horiike

Keishi Mizuguchi

Yohei Shinmyo

Hiroshi Kawasaki

Affiliations

Soon will be listed here.

Abstract

Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood-brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.

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