The IFT20 Homolog in is Required for Ciliogenesis and Cilia-mediated Behavior

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2021 May 17

PMID 33997658

Citations 3

Authors

Ana R G De-Castro

Joana Quintas-Goncalves

Tiago Silva-Ribeiro

Diogo R M Rodrigues

Maria J G De-Castro

Carla M Abreu

Tiago J Dantas

Affiliations

Soon will be listed here.

Abstract

Cilia are microtubule-based organelles that carry out a wide range of critical functions throughout the development of higher animals. Regardless of their type, all cilia rely on a motor-driven, bidirectional transport system known as intraflagellar transport (IFT). Of the many components of the IFT machinery, IFT20 is one of the smallest subunits. Nevertheless, IFT20 has been shown to play critical roles in the assembly of several types of mammalian cilia. Here we show that the IFT20 homolog in , IFT-20, is also important for correct cilium assembly in sensory neurons. Strikingly, however, we find that IFT-20-deficient animals are able to assemble short, vestigial cilia. In spite of this, we show that practically all IFT-20-deficient animals fail to respond to environmental cues that are normally detected by cilia to modulate their behavior. Altogether, our results indicate that IFT-20 is critical for both the correct assembly and function of cilia in .

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