A Retrospective Analysis of Patients with Short Stature in Eastern China Between 2013 and 2019

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 May 17

PMID 33997034

Citations 5

Authors

Qianqian Zhao

Mei Zhang

Yuntian Chu

Hailing Sun

Hui Pan

Bo Ban

Affiliations

Soon will be listed here.

Abstract

Objective: To identify the aetiology of growth and development diseases and assess the long-term effectiveness of recombinant human growth hormone (rhGH) therapy in a real-life clinical setting and provide better guidance in clinical strategy and decision making.

Methods: This retrospective study included 1145 children and adolescents with short stature admitted to the Department of Endocrinology, Affiliated Hospital of Jining Medical University, from January 2013 to December 2019, of whom 484 received rhGH treatment. The related anthropometrics and laboratory examinations were assessed in all participants.

Results: A total of 1145 children and adolescents with short stature aged 10.5 ± 3.3 years, including 740 boys and 405 girls, were analysed in this study. The number of children and adolescents with short stature gradually increased per year from 2013 to 2019. The mean pretreatment height standard deviation score (SDS) and insulin-like growth factor-1 SDS were -2.93 ± 1.05 and -1.01 (-1.83--0.16), respectively. The majority of the children (658, 57.47%) were prepubescent. In total, 484 subjects aged 10.6 ± 3.2 years received rhGH and were followed up, and among them, 292 children were treated for more than one year. As the treatment time increased, the children's height SDS gradually increased, and most of them attained a height SDS within the normal range. The mean height SDS in children who were treated for more than one year was -3.0 ± 1.0 at baseline and gradually increased to -0.8 ± 0.3 by year 6. The results were consistent across subgroups of different aetiologies of short stature.

Conclusions: Increasing attention has been given to the height of children during the period of 2013-2019 in eastern China. The present findings indicate that children with short stature need to be referred to a specialist centre to diagnose the cause of growth failure and that short children receiving rhGH therapy show a significant increase in height over time.

Citing Articles

Insights into the ANKRD11 variants and short-stature phenotype through literature review and ClinVar database search.

He D, Zhang M, Li Y, Liu F, Ban B Orphanet J Rare Dis. 2024; 19(1):292.

PMID: 39135054 PMC: 11318275. DOI: 10.1186/s13023-024-03301-y.

Non-linear relationship between sleep duration and blood pressure in children with short stature.

Zhao Q, He M, Zhang M, Chu Y, Ban B Front Pediatr. 2023; 11:1302750.

PMID: 38027291 PMC: 10657848. DOI: 10.3389/fped.2023.1302750.

CTCF variant begets to short stature by down-regulation of IGF1.

Chen H, Li W, Zhang S, Sun Y, Shen Y, Chen R J Mol Endocrinol. 2023; 70(4).

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Height outcomes in Korean children with idiopathic short stature receiving growth hormone treatment.

Chae H, Hwang I, Lee J, So C, Rhie Y, Lim J Front Endocrinol (Lausanne). 2022; 13:925102.

PMID: 36157444 PMC: 9490583. DOI: 10.3389/fendo.2022.925102.

Association Between the Growth Hormone/Insulin-Like Growth Factor-1 Axis and Muscle Density in Children and Adolescents of Short Stature.

Yang G, Yang Q, Li Y, Zhang Y, Chen S, He D Front Endocrinol (Lausanne). 2022; 13:920200.

PMID: 35774144 PMC: 9238351. DOI: 10.3389/fendo.2022.920200.

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