Repulsive Guidance Molecule-a and Central Nervous System Diseases

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 May 17

PMID 33997000

Citations 7

Authors

Jinhua Tang

Xiaopeng Zeng

Hang Li

Lu Ju

Jinzhou Feng

Jun Yang

Affiliations

Soon will be listed here.

Abstract

Repulsive guidance molecule-a (RGMa) is a member of glycosylphosphatidylinositol- (GPI-) anchored protein family, which has axon guidance function and is widely involved in the development and pathological processes of the central nervous system (CNS). On the one hand, the binding of RGMa and its receptor Neogenin can regulate axonal guidance, differentiation of neural stem cells into neurons, and the survival of these cells; on the other hand, RGMa can inhibit functional recovery of CNS by inhibiting axonal growth. A number of studies have shown that RGMa may be involved in the pathogenesis of CNS diseases, such as multiple sclerosis, neuromyelitis optica spectrum diseases, cerebral infarction, spinal cord injury, Parkinson's disease, and epilepsy. Targeting RGMa can enhance the functional recovery of CNS, so it may become a promising target for the treatment of CNS diseases. This article will comprehensively review the research progression of RGMa in various CNS diseases up to date.

Citing Articles

Artificial Microglia Nanoplatform Loaded With Anti-RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke.

Cheng R, Luo X, Wu X, Wang Z, Chen Z, Zhang S Adv Sci (Weinh). 2024; 11(48):e2410529.

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Characterization of Circulating Protein Profiles in Individuals with Prader-Willi Syndrome and Individuals with Non-Syndromic Obesity.

Pascut D, Giraudi P, Banfi C, Ghilardi S, Tiribelli C, Bondesan A J Clin Med. 2024; 13(19).

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A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort.

Annevelink C, Westra J, Sala-Vila A, Harris W, Tintle N, Shearer G J Nutr. 2023; 154(5):1640-1651.

PMID: 38141771 PMC: 11347816. DOI: 10.1016/j.tjnut.2023.12.035.

Increase in repulsive guidance molecule-a (RGMa) in lacunar and cortical stroke patients is related to the severity of the insult.

Parray A, Akhtar N, Pir G, Pananchikkal S, Ayadathil R, Mir F Sci Rep. 2022; 12(1):20788.

PMID: 36456640 PMC: 9715939. DOI: 10.1038/s41598-022-24481-2.

Selecting Genetic Variants and Interactions Associated with Amyotrophic Lateral Sclerosis: A Group LASSO Approach.

Feronato S, Silva M, Izbicki R, Farias T, Shigunov P, Dallagiovanna B J Pers Med. 2022; 12(8).

PMID: 36013279 PMC: 9410070. DOI: 10.3390/jpm12081330.

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