Assessing the Topical Application Efficiency of Two Biological Agents in Managing Chemotherapy-induced Oral Mucositis in Children: A Randomized Clinical Trial

Overview

Journal J Oral Biol Craniofac Res

Publisher Elsevier

Date 2021 May 17

PMID 33996432

Citations 5

Authors

Muaaz AlKhouli

Mohannad Laflouf

John C Comisi

Affiliations

Soon will be listed here.

Abstract

Background: oral mucositis is one of the most annoying complications of chemotherapy. This randomized clinical trial aimed to assess the efficiency of Aloe Vera and Olive Oil in managing chemotherapy-induced oral mucositis.

Methods: 36 children between 6 and 9 years and suffering from grade 3 or 4 oral mucositis, according to the World Health Organization (W.H.O.) scale, were enrolled in this clinical trial. Participants were separated into three groups to treat their mucositis using Aloe Vera, Olive Oil, or sodium bicarbonate. Nurses administrated the agents four times daily with sponge sticks. Two blinded investigators examined the oral mucosa after ten days.

Results: Both Aloe Vera and Olive Oil significant differences in the management of chemotherapy-induced oral mucositis compared to sodium bicarbonate treatments.

Conclusions: Olive Oil is effective in managing CIOM.

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