Microvascular Disease and Cardiovascular Outcomes Among Individuals with Type 2 Diabetes

Overview

Journal Diabetes Res Clin Pract

Specialty Endocrinology

Date 2021 May 14

PMID 33989668

Citations 12

Authors

Arnaud D Kaze

Prasanna Santhanam

Sebhat Erqou

Alain G Bertoni

Rexford S Ahima

Justin B Echouffo-Tcheugui

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the associations of microvascular disease (MVD) with incident cardiovascular disease (CVD) in individuals with type 2 diabetes.

Methods: A total of 4098 participants with type 2 diabetes and without CVD were assessed for MVD (diabetic kidney disease, retinopathy or neuropathy) in the Look AHEAD (Action for Health in Diabetes) study. Cox models were used to generate hazard ratios (HRs) for: (1) CVD composite (myocardial infarction, stroke, hospitalization for angina and/or death from cardiovascular causes), (2) coronary artery disease (CAD), (3) stroke, and (4) CVD-related deaths.

Results: Of 4098 participants, 34.7% (n = 1424) had MVD at baseline. Over a median of 9.5 years, 487 developed the CVD composite, 410 CAD events, 100 stroke, and 54 CVD-related deaths. After adjusting for relevant confounders, MVD was associated with increased risks of CVD composite (HR 1.34, 95% CI 1.11-1.61), CAD (HR 1.24, 95% CI 1.01-1.52), stroke (HR 1.55, 95% CI 1.03-2.33), and cardiovascular mortality (HR 1.26, 95% CI 0.72-2.22). HRs for CVD composite by type of MVD were 1.11 (95% CI 0.89-1.38), 1.63 (95% CI 1.22-2.17) and 1.16 (95% CI 0.92-1.46) for diabetic kidney disease, retinopathy, and neuropathy, respectively.

Conclusions: Our findings underscore the relevance of MVD in CVD risk assessment in type 2 diabetes.

Citing Articles

Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes.

Kaze A, Santhanam P, Ahima R, Bertoni A, Echouffo-Tcheugui J Diabetes Care. 2024; 47(8):1408-1414.

PMID: 38837904 PMC: 11272972. DOI: 10.2337/dc24-0294.

Impact of Fat Distribution and Metabolic Diseases on Cerebral Microcirculation: A Multimodal Study on Type 2 Diabetic and Obese Patients.

Esze R, Balkay L, Barna S, Szatmarine Egeresi L, Emri M, Pall D J Clin Med. 2024; 13(10).

PMID: 38792441 PMC: 11122647. DOI: 10.3390/jcm13102900.

Oxidative Stress, Endothelial Dysfunction, and -Acetylcysteine in Type 2 Diabetes Mellitus.

Li X, Zou J, Lin A, Chi J, Hao H, Chen H Antioxid Redox Signal. 2024; 40(16-18):968-989.

PMID: 38497734 PMC: 11535463. DOI: 10.1089/ars.2023.0524.

New Insights into Cardiovascular Diseases Treatment Based on Molecular Targets.

Wojtasinska A, Kucmierz J, Tokarek J, Dybiec J, Rodzen A, Mlynarska E Int J Mol Sci. 2023; 24(23).

PMID: 38069058 PMC: 10706703. DOI: 10.3390/ijms242316735.

Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer's Disease.

Mohamed-Mohamed H, Garcia-Morales V, Sanchez Lara E, Gonzalez-Acedo A, Pardo-Moreno T, Tovar-Galvez M Neurol Int. 2023; 15(4):1253-1272.

PMID: 37873836 PMC: 10594452. DOI: 10.3390/neurolint15040079.

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