Early Postnatal Metabolic Profile in Neonates With Different Birth Weight Status: A Pilot Study

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2021 May 14

PMID 33987152

Citations 5

Authors

Serdar Beken

Saygin Abali

Neslihan Yildirim Saral

Bengisu Guner

Taha Dinc

Eda Albayrak

Melike Ersoy

Meltem Kilercik

Muge Halici

Ezgi Bulbul

Didem Kaya

Melis Karabay

Zeynep Alize Ay

Gulten Zeynep Eksi

Fehime Benli Aksungar

Ayse Korkmaz

Mustafa Serteser

Affiliations

Soon will be listed here.

Abstract

Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this study, the relationship between intrauterine growth status and early metabolomics profile was evaluated. A single-center retrospective cohort study was conducted. Three hundred and sixty-one newborn infants were enrolled into the study, and they were grouped according to their birth weight percentile as small for gestational age (SGA, = 69), appropriate for gestational age (AGA, = 168), and large for gestational age (LGA, = 124) infants. In all infants, amino acid and carnitine/acylcarnitine profiles with liquid chromatography-tandem mass spectrometry (LC-MS/MS) were recorded and compared between groups. LGA infants had higher levels of glutamic acid and lower levels of ornithine, alanine, and glycine ( < 0.05) when compared with AGA infants. SGA infants had higher levels of alanine and glycine levels when compared with AGA and LGA infants. Total carnitine, C0, C2, C4, C5, C10:1, C18:1, C18:2, C14-OH, and C18:2-OH levels were significantly higher and C3 and C6-DC levels were lower in SGA infants ( < 0.05). LGA infants had higher C3 and C5:1 levels and lower C18:2 and C16:1-OH levels ( < 0.05). There were positive correlations between free carnitine and phenylalanine, arginine, methionine, alanine, and glycine levels ( < 0.05). Also, a positive correlation between ponderal index and C3, C5-DC, C14, and C14:1 and a negative correlation between ponderal index and ornithine, alanine, glycine, C16:1-OH, and C18:2 were shown. We demonstrated differences in metabolomics possibly reflecting the energy metabolism in newborn infants with intrauterine growth problems in the early postnatal period. These differences might be the footprints of metabolic disturbances in future adulthood.

Citing Articles

Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review.

Conde-Agudelo A, Villar J, Risso M, Papageorghiou A, Roberts L, Kennedy S Nat Commun. 2024; 15(1):9752.

PMID: 39528475 PMC: 11555221. DOI: 10.1038/s41467-024-53597-4.

Investigation of newborn blood metabolomics in varying intrauterine growth conditions.

Wang S, Lin X, Zhou Y, Yang X, Ou M, Zhang L J Pediatr (Rio J). 2024; 101(1):74-81.

PMID: 39178913 PMC: 11763542. DOI: 10.1016/j.jped.2024.07.009.

Metabolomics of a neonatal cohort from the Alliance for Maternal and Newborn Health Improvement biorepository: Effect of preanalytical variables on reference intervals.

Jafri L, Khan A, Ilyas M, Nisar I, Khalid J, Majid H PLoS One. 2023; 18(1):e0279931.

PMID: 36607993 PMC: 9821480. DOI: 10.1371/journal.pone.0279931.

Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome.

Gonzalez-Riano C, Santos M, Diaz M, Garcia-Beltran C, Lerin C, Barbas C Nutrients. 2022; 14(18).

PMID: 36145136 PMC: 9505183. DOI: 10.3390/nu14183760.

Metabolomics Applied to Cord Serum in Preeclampsia Newborns: Implications for Neonatal Outcomes.

Wang X, Liu J, Hui X, Song Y Front Pediatr. 2022; 10:869381.

PMID: 35547553 PMC: 9082809. DOI: 10.3389/fped.2022.869381.

References

Mai M, Tonjes A, Kovacs P, Stumvoll M, Fiedler G, Leichtle A . Serum levels of acylcarnitines are altered in prediabetic conditions. PLoS One. 2013; 8(12):e82459. PMC: 3865089. DOI: 10.1371/journal.pone.0082459. View

Bene J, Hadzsiev K, Melegh B . Role of carnitine and its derivatives in the development and management of type 2 diabetes. Nutr Diabetes. 2018; 8(1):8. PMC: 5856836. DOI: 10.1038/s41387-018-0017-1. View

Vidarsdottir H, Thorkelsson T, Halldorsson T, Bjarnason R, Geirsson R, Rinaldo P . Does metabolomic profile differ with regard to birth weight?. Pediatr Res. 2020; 89(5):1144-1151. DOI: 10.1038/s41390-020-1033-0. View

Landmann E, Reiss I, Misselwitz B, Gortner L . Ponderal index for discrimination between symmetric and asymmetric growth restriction: percentiles for neonates from 30 weeks to 43 weeks of gestation. J Matern Fetal Neonatal Med. 2006; 19(3):157-60. DOI: 10.1080/14767050600624786. View

Oey N, van Vlies N, Wijburg F, Wanders R, Attie-Bitach T, Vaz F . L-carnitine is synthesized in the human fetal-placental unit: potential roles in placental and fetal metabolism. Placenta. 2005; 27(8):841-6. DOI: 10.1016/j.placenta.2005.10.002. View

Das S, Irigoyen M, PATTERSON M, Salvador A, Schutzman D . Neonatal outcomes of macrosomic births in diabetic and non-diabetic women. Arch Dis Child Fetal Neonatal Ed. 2009; 94(6):F419-22. DOI: 10.1136/adc.2008.156026. View

Quesnele J, Laframboise M, Wong J, Kim P, Wells G . The effects of beta-alanine supplementation on performance: a systematic review of the literature. Int J Sport Nutr Exerc Metab. 2013; 24(1):14-27. DOI: 10.1123/ijsnem.2013-0007. View

Liu Q, Wu J, Shen W, Wei R, Jiang J, Liang J . Analysis of amino acids and acyl carnitine profiles in low birth weight, preterm, and small for gestational age neonates. J Matern Fetal Neonatal Med. 2016; 30(22):2697-2704. DOI: 10.1080/14767058.2016.1261395. View

Zhang X, Yang S, Chen J, Su Z . Unraveling the Regulation of Hepatic Gluconeogenesis. Front Endocrinol (Lausanne). 2019; 9:802. PMC: 6353800. DOI: 10.3389/fendo.2018.00802. View

10.

Novak M, MONKUS E, Chung D, BUCH M . Carnitine in the perinatal metabolism of lipids. I. Relationship between maternal and fetal plasma levels of carnitine and acylcarnitines. Pediatrics. 1981; 67(1):95-100. View

11.

Finken M, van der Steen M, Smeets C, Walenkamp M, de Bruin C, Hokken-Koelega A . Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications. Endocr Rev. 2018; 39(6):851-894. DOI: 10.1210/er.2018-00083. View

12.

Manta-Vogli P, Schulpis K, Loukas Y, Dotsikas Y . Quantitation of the arginine family amino acids in the blood of full-term infants perinatally in relation to their birth weight. J Pediatr Endocrinol Metab. 2019; 32(8):803-809. DOI: 10.1515/jpem-2019-0146. View

13.

Demir K, Konakci E, Ozkaya G, Demir B, Ozen S, Aydin M . New Features for Child Metrics: Further Growth References and Blood Pressure Calculations. J Clin Res Pediatr Endocrinol. 2019; 12(2):125-129. PMC: 7291402. DOI: 10.4274/jcrpe.galenos.2019.2019.0127. View

14.

Manta-Vogli P, Schulpis K, Loukas Y, Dotsikas Y . Perinatal free carnitine and short chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns in relation to their birth weight. Pediatr Neonatol. 2020; 61(6):620-628. DOI: 10.1016/j.pedneo.2020.07.015. View

15.

Schooneman M, Vaz F, Houten S, Soeters M . Acylcarnitines: reflecting or inflicting insulin resistance?. Diabetes. 2012; 62(1):1-8. PMC: 3526046. DOI: 10.2337/db12-0466. View

16.

Magi S, Piccirillo S, Amoroso S . The dual face of glutamate: from a neurotoxin to a potential survival factor-metabolic implications in health and disease. Cell Mol Life Sci. 2019; 76(8):1473-1488. PMC: 11105246. DOI: 10.1007/s00018-018-3002-x. View

17.

Liu J, Chen X, Li X, Fu W, Zhang W . Metabolomic Research on Newborn Infants With Intrauterine Growth Restriction. Medicine (Baltimore). 2016; 95(17):e3564. PMC: 4998730. DOI: 10.1097/MD.0000000000003564. View

18.

Hwang I . Long-term care, from neonatal period to adulthood, of children born small for gestational age. Clin Pediatr Endocrinol. 2019; 28(4):97-103. PMC: 6801360. DOI: 10.1297/cpe.28.97. View

19.

Lowe Jr W, Bain J, Nodzenski M, Reisetter A, Muehlbauer M, Stevens R . Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care. 2017; 40(7):902-910. PMC: 5481987. DOI: 10.2337/dc16-2452. View

20.

Sanchez-Pintos P, De Castro M, Roca I, Rite S, Lopez M, Couce M . Similarities between acylcarnitine profiles in large for gestational age newborns and obesity. Sci Rep. 2017; 7(1):16267. PMC: 5701125. DOI: 10.1038/s41598-017-15809-4. View