Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma

Overview

Journal Can J Gastroenterol Hepatol

Specialty Gastroenterology

Date 2021 May 14

PMID 33987145

Citations 5

Authors

Farshid Fathi

Behnam Sanei

Mazdak Ganjalikhani Hakemi

Reza F Saidi

Abbas Rezaei

Affiliations

Soon will be listed here.

Abstract

Background: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR.

Methods: Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), IL-1, IL-1 , IL-10, and transforming growth factor-beta1 (TGF-1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF- and IL-6 were also measured by ELISA.

Results: After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased ( < 0.001 - 0.05). The same trend was also observed in TNF- expression after 90 minutes of LR ( < 0.01). No significant changes were observed in the expressions of IL-1, IL-1, IL-10, and TGF-1 before and after LR. In addition, LR had significant effects on TNF- and IL-6 serum levels ( < 0.05 - 0.0001).

Conclusion: Our data provided further evidence to reveal that IL-6 and TNF- cytokines are critical to improve liver regeneration.

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