Lenalidomide-Associated Hemophagocytic Lymphohistiocytosis With Plasma Cell Phagocytosis

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2021 May 14

PMID 33987058

Citations 2

Authors

Elliot Runge

Chung-Ting J Kou

Matthew Rendo

David Lynch

Joshua Fenderson

Affiliations

Soon will be listed here.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe systemic inflammatory syndrome that is often fatal. In the adult population, it is believed to develop secondary to immune dysregulation due to rheumatologic, infectious, malignant, and recently, immunomodulatory drugs. It's co-occurrence with phagocytosis by non-macrophage cells has not been previously well defined. We present a case of lenalidomide-associated HLH with concurrent plasma cell hemophagocytosis in a patient with controlled multiple myeloma (MM).

Citing Articles

Myeloma-associated hemophagocytic lymphohistiocytosis - A comprehensive case study and a novel chemotherapy-free approach with anakinra.

Al-Ammari M, Hsu D, Bryant A EJHaem. 2024; 5(5):1057-1062.

PMID: 39415906 PMC: 11474360. DOI: 10.1002/jha2.975.

Secondary Hemophagocytic Syndrome in a Patient with Plasma Cell Myeloma and CNS Involvement Treated with Lenalidomide.

Milczarek S, Kulig P, Baumert B, Lanocha A, Sommerfeld K, Borowiecka E Medicina (Kaunas). 2022; 58(10).

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