Elevated Levels of Urine Isocitrate, Hydroxymethylglutarate, and Formiminoglutamate Are Associated with Arterial Stiffness in Korean Adults

Overview

Journal Sci Rep

Specialty Science

Date 2021 May 14

PMID 33986342

Citations 4

Authors

Ji-Hee Haam

Young-Sang Kim

Doo-Yeoun Cho

Hyejin Chun

Sang-Woon Choi

Yun Kyong Lee

Sang Wook Lim

Hyung Suk Koo

Moon Jong Kim

Affiliations

Soon will be listed here.

Abstract

Recent evidence suggests that cellular perturbations play an important role in the pathogenesis of cardiovascular diseases. Therefore, we analyzed the association between the levels of urinary metabolites and arterial stiffness. Our cross-sectional study included 330 Korean men and women. The brachial-ankle pulse wave velocity was measured as a marker of arterial stiffness. Urinary metabolites were evaluated using a high-performance liquid chromatograph-mass spectrometer. The brachial-ankle pulse wave velocity was found to be positively correlated with L-lactate, citrate, isocitrate, succinate, malate, hydroxymethylglutarate, α-ketoisovalerate, α-keto-β-methylvalerate, methylmalonate, and formiminoglutamate among men. Whereas, among women, the brachial-ankle pulse wave velocity was positively correlated with cis-aconitate, isocitrate, hydroxymethylglutarate, and formiminoglutamate. In the multivariable regression models adjusted for conventional cardiovascular risk factors, three metabolite concentrations (urine isocitrate, hydroxymethylglutarate, and formiminoglutamate) were independently and positively associated with brachial-ankle pulse wave velocity. Increased urine isocitrate, hydroxymethylglutarate, and formiminoglutamate concentrations were associated with brachial-ankle pulse wave velocity and independent of conventional cardiovascular risk factors. Our findings suggest that metabolic disturbances in cells may be related to arterial stiffness.

Citing Articles

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