Applications of Engineering Techniques in Microvasculature Design

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 May 13

PMID 33981737

Authors

Aleen Al Halawani

Ziyu Wang

Linyang Liu

Miao Zhang

Anthony S Weiss

Affiliations

Soon will be listed here.

Abstract

Achieving successful microcirculation in tissue engineered constructs and remains a challenge. Engineered tissue must be vascularized for successful inosculation post-implantation to allow instantaneous perfusion. To achieve this, most engineering techniques rely on engineering channels or pores for guiding angiogenesis and capillary tube formation. However, the chosen materials should also exhibit properties resembling the native extracellular matrix (ECM) in providing mechanical and molecular cues for endothelial cells. This review addresses techniques that can be used in conjunction with matrix-mimicking materials to further advance microvasculature design. These include electrospinning, micropatterning and bioprinting. Other techniques implemented for vascularizing organoids are also considered for their potential to expand on these approaches.

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