Cardioprotection Stimulated by Resveratrol and Grape Products Prevents Lethal Cardiac Arrhythmias in an Animal Model of Ischemia and Reperfusion

Overview

Journal Acta Cir Bras

Specialty General Surgery

Date 2021 May 12

PMID 33978062

Citations 8

Authors

Francisco Sandro Menezes-Rodrigues

Paolo Ruggero Errante

Erisvaldo Amarante Araujo

Mariana Pontes Pacheco Fernandes

Michele Mendes da Silva

Marcelo Pires-Oliveira

Carla Alessandra Scorza

Fulvio Alexandre Scorza

Murched Omar Taha

Afonso Caricati-Neto

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as grape juice and red wine, in animal model of cardiac ischemia and reperfusion.

Methods: Male Wistar rats orally pretreated for 21-days with resveratrol and grape products were anesthetized and placed on mechanical ventilation to surgically induce cardiac ischemia and reperfusion by obstruction (ischemia) followed by liberation (reperfusion) of blood circulation in left descending coronary artery. These rats were submitted to the electrocardiogram (ECG) analysis to evaluate the effects of pretreatment with resveratrol and grape products on the incidence of ventricular arrhythmias (VA), atrioventricular block (AVB) and lethality (LET) resulting from cardiac ischemia and reperfusion.

Results: It was observed that the incidence of AVB was significantly lower in rats pretreated with resveratrol (25%), grape juice (37.5%) or red wine (12.5%) than in rats treated with saline solution (80%) or ethanol (80%). Similarly, incidence of LET was also significantly lower in rats pretreated with resveratrol (25%), grape juice (25%) or red wine (0%) than in rats treated with saline solution (62.5%) or ethanol (75%).

Conclusions: These results indicate that the cardioprotective response stimulated by resveratrol and grape products prevents the lethal cardiac arrhythmias in animal model of ischemia and reperfusion, supporting the idea that this treatment can be beneficial for prevention of severe cardiac arrhythmias in patients with ischemic heart disease.

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