Anti-IL-17 Agents in the Treatment of Axial Spondyloarthritis

Overview

Journal Immunotargets Ther

Publisher Dove Medical Press

Specialty Allergy & Immunology

Date 2021 May 12

PMID 33977094

Citations 13

Authors

Fabiola Atzeni

Antonio Carriero

Laura Boccassini

Salvatore DAngelo

Affiliations

Soon will be listed here.

Abstract

Axial spondyloarthritis (axSpA) describes a group of chronic inflammatory rheumatic diseases primarily involving the axial skeleton. IL-17 is involved in the pathogenesis of numerous inflammatory diseases, including inflammatory arthritis. Until a few years ago, the only biological agents licensed for the treatment of axSpA and nr-axSpA were TNF inhibitors. However, as some patients did not respond to TNF inhibition or experienced secondary failure, the introduction of the first two IL-17 inhibitors (secukinumab [SEC] and ixekizumab [IXE]) has extended the treatment options, and there are now three others (bimekizumab, brodalumab and netakimab) in various stages of clinical development. The last ten years have seen the development of a number of therapeutic recommendations that aimed at improving the management of axSpA patients. The aim of this narrative review of the published literature concerning the role of IL-17 in the pathogenesis of SpA, and the role of IL-17 inhibitors in the treatment of axSpA, is to provide a comprehensive picture of the clinical efficacy and safety of the drugs themselves, and the treatment strategies recommended in the international guidelines.

Citing Articles

A systematic review of the role of interleukin-17 inhibitors in bullous pemphigoid: therapeutic and paradoxical effects.

Heidari N, Hosseini S, Heidari A, Ghane Y, Daneshpazhooh M, Mahmoudi H Arch Dermatol Res. 2025; 317(1):544.

PMID: 40067544 DOI: 10.1007/s00403-025-04052-x.

Progress in targeted therapy for ankylosing spondylitis: A review.

Wang J, Lou W, Li Y, Jiang Y, Jiang X, Yang L Medicine (Baltimore). 2024; 103(48):e40742.

PMID: 39612456 PMC: 11608699. DOI: 10.1097/MD.0000000000040742.

Zrour S, Dridi A, Grassa R, Ben Chekaya N, Bejia I Tunis Med. 2024; 102(11):910-915.

PMID: 39564635 PMC: 11668151. DOI: 10.62438/tunismed.v102i11.5059.

Ixekizumab Treatment Patterns and Health Care Resource Utilization Among Patients with Axial Spondyloarthritis: A Retrospective United States Claims Database Study.

Danve A, Vadhariya A, Lisse J, Cholayil A, Bansal N, Bello N Rheumatol Ther. 2024; 11(5):1333-1345.

PMID: 39162898 PMC: 11422398. DOI: 10.1007/s40744-024-00710-0.

Differentiation and regulation of CD4 T cell subsets in Parkinson's disease.

Sun X, Gu R, Bai J Cell Mol Life Sci. 2024; 81(1):352.

PMID: 39153043 PMC: 11335276. DOI: 10.1007/s00018-024-05402-0.

References

Lubberts E, Koenders M, van den Berg W . The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther. 2005; 7(1):29-37. PMC: 1064899. DOI: 10.1186/ar1478. View

Hazenberg M, Spits H . Human innate lymphoid cells. Blood. 2014; 124(5):700-9. DOI: 10.1182/blood-2013-11-427781. View

Ward M, Deodhar A, Gensler L, Dubreuil M, Yu D, Khan M . 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Rheumatol. 2019; 71(10):1599-1613. PMC: 6764882. DOI: 10.1002/art.41042. View

Papp K, Leonardi C, Menter A, Ortonne J, Krueger J, Kricorian G . Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med. 2012; 366(13):1181-9. DOI: 10.1056/NEJMoa1109017. View

Schwarzenberger P, La Russa V, Miller A, Ye P, Huang W, Zieske A . IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol. 1998; 161(11):6383-9. View

Sorbello V, Ciprandi G, Di Stefano A, Massaglia G, Favata G, Conticello S . Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma. Allergy. 2014; 70(2):236-40. DOI: 10.1111/all.12547. View

Taurog J, Chhabra A, Colbert R . Ankylosing Spondylitis and Axial Spondyloarthritis. N Engl J Med. 2016; 375(13):1303. DOI: 10.1056/NEJMc1609622. View

Watanabe R, Gehad A, Yang C, Scott L, Teague J, Schlapbach C . Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Transl Med. 2015; 7(279):279ra39. PMC: 4425193. DOI: 10.1126/scitranslmed.3010302. View

Gillet P, Bannwarth B, Charriere G, Leroux P, Fener P, Netter P . Studies on type II collagen induced arthritis in rats: an experimental model of peripheral and axial ossifying enthesopathy. J Rheumatol. 1989; 16(6):721-8. View

10.

Soare A, Weber S, Maul L, Rauber S, Gheorghiu A, Luber M . Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis. J Immunol. 2018; 200(4):1249-1254. DOI: 10.4049/jimmunol.1700596. View

11.

Deodhar A, Mease P, Reveille J, Curtis J, Chen S, Malhotra K . Frequency of Axial Spondyloarthritis Diagnosis Among Patients Seen by US Rheumatologists for Evaluation of Chronic Back Pain. Arthritis Rheumatol. 2016; 68(7):1669-76. PMC: 5094500. DOI: 10.1002/art.39612. View

12.

Noordenbos T, Blijdorp I, Chen S, Stap J, Mul E, Canete J . Human mast cells capture, store, and release bioactive, exogenous IL-17A. J Leukoc Biol. 2016; 100(3):453-62. DOI: 10.1189/jlb.3HI1215-542R. View

13.

Bush K, Farmer K, Walker J, Kirkham B . Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. 2002; 46(3):802-5. DOI: 10.1002/art.10173. View

14.

Ortega C, Fernandez-A S, Carrillo J, Romero P, Molina I, Moreno J . IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J Leukoc Biol. 2009; 86(2):435-43. DOI: 10.1189/JLB.0109046. View

15.

Friday S, Fox D . Phospholipase D enzymes facilitate IL-17- and TNFα-induced expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF). Immunol Lett. 2016; 174:9-18. DOI: 10.1016/j.imlet.2016.04.001. View

16.

Chang S, Dong C . A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 2007; 17(5):435-40. DOI: 10.1038/cr.2007.35. View

17.

Cai Y, Shen X, Ding C, Qi C, Li K, Li X . Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity. 2011; 35(4):596-610. PMC: 3205267. DOI: 10.1016/j.immuni.2011.08.001. View

18.

Leipe J, Grunke M, Dechant C, Reindl C, Kerzendorf U, Schulze-Koops H . Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum. 2010; 62(10):2876-85. DOI: 10.1002/art.27622. View

19.

Hayashi E, Chiba A, Tada K, Haga K, Kitagaichi M, Nakajima S . Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis. J Rheumatol. 2016; 43(9):1695-703. DOI: 10.3899/jrheum.151133. View

20.

Shahrara S, Pickens S, Mandelin 2nd A, Karpus W, Huang Q, Kolls J . IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction. J Immunol. 2010; 184(8):4479-87. PMC: 2858914. DOI: 10.4049/jimmunol.0901942. View