A Reply to 'Alteration of Steroidogenesis in Boys with Autism Spectrum Disorders'

Overview

Journal Transl Psychiatry

Specialties Psychiatry
Public Health

Date 2021 May 11

PMID 33972510

Citations 4

Authors

Benedikt Andreas Gasser

Johann Kurz

Bernhard Dick

Markus Georg Mohaupt

Affiliations

Soon will be listed here.

Citing Articles

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Light in the Rational Treatment of Autism? Effects of Metformin on Steroid Hormones in a Patient with Polycystic Ovarian Syndrome (PCOS).

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Metformin-Treatment Option for Social Impairment? An Open Clinical Trial to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior.

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Hyperandrogenism? Increased 17, 20-Lyase Activity? A Metanalysis and Systematic Review of Altered Androgens in Boys and Girls with Autism.

Gasser B, Buerki S, Kurz J, Mohaupt M Int J Mol Sci. 2021; 22(22).

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References

Majewska M, Hill M, Urbanowicz E, Rok-Bujko P, Bienkowski P, Namyslowska I . Marked elevation of adrenal steroids, especially androgens, in saliva of prepubertal autistic children. Eur Child Adolesc Psychiatry. 2013; 23(6):485-98. PMC: 4042015. DOI: 10.1007/s00787-013-0472-0. View

Gillberg C, Fernell E, Kocovska E, Minnis H, Bourgeron T, Thompson L . The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper. Autism Res. 2017; 10(6):1022-1044. PMC: 5485071. DOI: 10.1002/aur.1777. View

Fukami M, Homma K, Hasegawa T, Ogata T . Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development. Dev Dyn. 2012; 242(4):320-9. DOI: 10.1002/dvdy.23892. View

Stein T, Schluter M, Steer R, Ming X . Autism and phthalate metabolite glucuronidation. J Autism Dev Disord. 2013; 43(11):2677-85. PMC: 3797149. DOI: 10.1007/s10803-013-1822-y. View

Miller W, Auchus R . The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev. 2010; 32(1):81-151. PMC: 3365799. DOI: 10.1210/er.2010-0013. View

MARGOLESE M, JANIGER O . Androsterone-etiocholanolone ratios in male homosexuals. Br Med J. 1973; 3(5873):207-10. PMC: 1586258. DOI: 10.1136/bmj.3.5873.207. View

JOHNSEN S . Abnormal urinary androsterone/etiocholanolone ratio in hypothalamic disturbances in man. Acta Endocrinol (Copenh). 1968; 57(4):595-614. DOI: 10.1530/acta.0.0570595. View

Auchus R . The backdoor pathway to dihydrotestosterone. Trends Endocrinol Metab. 2004; 15(9):432-8. DOI: 10.1016/j.tem.2004.09.004. View

Hu V, Sarachana T, Sherrard R, Kocher K . Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism. Mol Autism. 2015; 6:7. PMC: 4459681. DOI: 10.1186/2040-2392-6-7. View

10.

Kamrath C, Hochberg Z, Hartmann M, Remer T, Wudy S . Increased activation of the alternative "backdoor" pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis. J Clin Endocrinol Metab. 2011; 97(3):E367-75. DOI: 10.1210/jc.2011-1997. View

11.

OShaughnessy P, Antignac J, Le Bizec B, Morvan M, Svechnikov K, Soder O . Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biol. 2019; 17(2):e3000002. PMC: 6375548. DOI: 10.1371/journal.pbio.3000002. View

12.

Sarachana T, Xu M, Wu R, Hu V . Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One. 2011; 6(2):e17116. PMC: 3040206. DOI: 10.1371/journal.pone.0017116. View

13.

Dhayat N, Dick B, Frey B, dUscio C, Vogt B, Fluck C . Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from the urinary steroid metabolome. J Steroid Biochem Mol Biol. 2016; 165(Pt B):312-322. DOI: 10.1016/j.jsbmb.2016.07.009. View

14.

Gasser B, Kurz J, Mohaupt M . Testosterone/Epitestosterone Ratios-Further Hints to Explain Hyperandrogenemia in Children with Autism. Diseases. 2021; 9(1). PMC: 7931062. DOI: 10.3390/diseases9010013. View

15.

Opt Hof J, Johnstone J, Venter P . Hormone studies in patients with the Martin-Bell syndrome. S Afr Med J. 1983; 63(3):65. View

16.

Homma K, Hasegawa T, Nagai T, Adachi M, Horikawa R, Fujiwara I . Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone. J Clin Endocrinol Metab. 2006; 91(7):2643-9. DOI: 10.1210/jc.2005-2460. View

17.

Ackermann D, Groessl M, Pruijm M, Ponte B, Escher G, dUscio C . Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis. PLoS One. 2019; 14(3):e0214549. PMC: 6440635. DOI: 10.1371/journal.pone.0214549. View

18.

Arlt W, Walker E, Draper N, Ivison H, Ride J, Hammer F . Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Lancet. 2004; 363(9427):2128-35. DOI: 10.1016/S0140-6736(04)16503-3. View

19.

Fluck C, Meyer-Boni M, Pandey A, Kempna P, Miller W, Schoenle E . Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. Am J Hum Genet. 2011; 89(2):201-18. PMC: 3155178. DOI: 10.1016/j.ajhg.2011.06.009. View

20.

Gasser B, Kurz J, Dick B, Mohaupt M . Are Steroid Hormones Dysregulated in Autistic Girls?. Diseases. 2020; 8(1). PMC: 7151154. DOI: 10.3390/diseases8010006. View