Rebuilding the Vascular Network: and Approaches

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 May 10

PMID 33968926

Citations 16

Authors

Xiangfu Meng

Yunhui Xing

Jiawen Li

Cechuan Deng

Yifei Li

Xi Ren

Donghui Zhang

Affiliations

Soon will be listed here.

Abstract

As the material transportation system of the human body, the vascular network carries the transportation of materials and nutrients. Currently, the construction of functional microvascular networks is an urgent requirement for the development of regenerative medicine and drug screening systems. How to construct organs with functional blood vessels is the focus and challenge of tissue engineering research. Here in this review article, we first introduced the basic characteristics of blood vessels in the body and the mechanism of angiogenesis , summarized the current methods of constructing tissue blood vessels and , and focused on comparing the functions, applications and advantages of constructing different types of vascular chips to generate blood vessels. Finally, the challenges and opportunities faced by the development of this field were discussed.

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