Vaccine-Induced Immunological Memory in Invasive Fungal Infections - A Dream So Close Yet So Far

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 May 10

PMID 33968079

Citations 9

Authors

Partha S Biswas

Affiliations

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Abstract

The invasive fungal infections (IFIs) are a major cause of mortality due to infectious disease worldwide. Majority of the IFIs are caused by opportunistic fungi including , and species. Lack of approved antifungal vaccines and the emergence of antifungal drug-resistant strains pose major constraints in controlling IFIs. A comprehensive understanding of the host immune response is required to develop novel fungal vaccines to prevent death from IFIs. In this review, we have discussed the challenges associated with the development of antifungal vaccines. We mentioned how host-pathogen interactions shape immunological memory and development of long-term protective immunity to IFIs. Furthermore, we underscored the contribution of long-lived innate and adaptive memory cells in protection against IFIs and summarized the current vaccine strategies.

Citing Articles

Invasive Fungal Infections in Immunocompromised Conditions: Emphasis on COVID-19.

Kaur M, Thakur P, Verma N, Choksket S, Harshvardhan , Korpole S Curr Microbiol. 2024; 81(11):400.

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Vaccine Strategies for Cryptococcus neoformans.

Brauer V, Querobino S, Matos G, Dasilva D, Del Poeta M Methods Mol Biol. 2024; 2775():411-422.

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Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections.

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References

Edwards J . Fungal cell wall vaccines: an update. J Med Microbiol. 2012; 61(Pt 7):895-903. PMC: 3542710. DOI: 10.1099/jmm.0.041665-0. View

Balish E, Wagner R, Vazquez-Torres A, Pierson C, Warner T . Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis. 1998; 178(2):478-87. DOI: 10.1086/515645. View

Gelfand J, Hurley D, Fauci A, Frank M . Role of complement in host defense against experimental disseminated candidiasis. J Infect Dis. 1978; 138(1):9-16. DOI: 10.1093/infdis/138.1.9. View

Sun J, Ugolini S, Vivier E . Immunological memory within the innate immune system. EMBO J. 2014; 33(12):1295-303. PMC: 4194120. DOI: 10.1002/embj.201387651. View

Feldmesser M . Prospects of vaccines for invasive aspergillosis. Med Mycol. 2006; 43(7):571-87. DOI: 10.1080/13693780500402138. View

Klebanoff C, Gattinoni L, Torabi-Parizi P, Kerstann K, Cardones A, Finkelstein S . Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A. 2005; 102(27):9571-6. PMC: 1172264. DOI: 10.1073/pnas.0503726102. View

Conti H, Gaffen S . IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans. J Immunol. 2015; 195(3):780-8. PMC: 4507294. DOI: 10.4049/jimmunol.1500909. View

Liu M, Clemons K, Bigos M, Medovarska I, Brummer E, Stevens D . Immune responses induced by heat killed Saccharomyces cerevisiae: a vaccine against fungal infection. Vaccine. 2011; 29(9):1745-53. PMC: 5508752. DOI: 10.1016/j.vaccine.2010.12.119. View

Nanjappa S, Klein B . Vaccine immunity against fungal infections. Curr Opin Immunol. 2014; 28:27-33. PMC: 4037332. DOI: 10.1016/j.coi.2014.01.014. View

10.

Moragues M, Omaetxebarria M, Elguezabal N, Sevilla M, Conti S, Polonelli L . A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities. Infect Immun. 2003; 71(9):5273-9. PMC: 187351. DOI: 10.1128/IAI.71.9.5273-5279.2003. View

11.

Kleinnijenhuis J, Quintin J, Preijers F, Joosten L, Jacobs C, Xavier R . BCG-induced trained immunity in NK cells: Role for non-specific protection to infection. Clin Immunol. 2014; 155(2):213-9. PMC: 5084088. DOI: 10.1016/j.clim.2014.10.005. View

12.

Urban C, Ermert D, Schmid M, Abu-Abed U, Goosmann C, Nacken W . Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog. 2009; 5(10):e1000639. PMC: 2763347. DOI: 10.1371/journal.ppat.1000639. View

13.

Nanjappa S, Heninger E, Wuthrich M, Gasper D, Klein B . Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog. 2012; 8(7):e1002771. PMC: 3400565. DOI: 10.1371/journal.ppat.1002771. View

14.

Wuthrich M, Filutowicz H, Warner T, Deepe Jr G, Klein B . Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. J Exp Med. 2003; 197(11):1405-16. PMC: 2193905. DOI: 10.1084/jem.20030109. View

15.

Bourgeois C, Kuchler K . Fungal pathogens-a sweet and sour treat for toll-like receptors. Front Cell Infect Microbiol. 2012; 2:142. PMC: 3504294. DOI: 10.3389/fcimb.2012.00142. View

16.

Netea M, Gijzen K, Coolen N, Verschueren I, Figdor C, van der Meer J . Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages. Microbes Infect. 2004; 6(11):985-9. DOI: 10.1016/j.micinf.2004.05.013. View

17.

Whitney P, Bar E, Osorio F, Rogers N, Schraml B, Deddouche S . Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathog. 2014; 10(7):e1004276. PMC: 4102599. DOI: 10.1371/journal.ppat.1004276. View

18.

Moriyama B, Gordon L, McCarthy M, Henning S, Walsh T, Penzak S . Emerging drugs and vaccines for candidemia. Mycoses. 2014; 57(12):718-33. PMC: 4269330. DOI: 10.1111/myc.12265. View

19.

Herring A, Lee J, McDonald R, Toews G, Huffnagle G . Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection. Infect Immun. 2002; 70(6):2959-64. PMC: 127967. DOI: 10.1128/IAI.70.6.2959-2964.2002. View

20.

Romani L, Mencacci A, Cenci E, Spaccapelo R, Schiaffella E, Tonnetti L . Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice. Infect Immun. 1993; 61(9):3769-74. PMC: 281076. DOI: 10.1128/iai.61.9.3769-3774.1993. View