Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Overview

Journal Hypertension

Date 2021 May 10

PMID 33966451

Citations 47

Authors

Vienna E Brunt

Abigail G Casso

Rachel A Gioscia-Ryan

Zachary J Sapinsley

Brian P Ziemba

Zachary S Clayton

Amy E Bazzoni

Nicholas S VanDongen

James J Richey

David A Hutton

Melanie C Zigler

Andrew P Neilson

Kevin P Davy

Douglas R Seals

Affiliations

Soon will be listed here.

Abstract

[Figure: see text].

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References

Gioscia-Ryan R, Clayton Z, Fleenor B, Eng J, Johnson L, Rossman M . Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening. Geroscience. 2020; 43(1):423-432. PMC: 8050175. DOI: 10.1007/s11357-020-00212-1. View

Zieman S, Melenovsky V, Kass D . Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005; 25(5):932-43. DOI: 10.1161/01.ATV.0000160548.78317.29. View

Lyle A, Raaz U . Killing Me Unsoftly: Causes and Mechanisms of Arterial Stiffness. Arterioscler Thromb Vasc Biol. 2017; 37(2):e1-e11. PMC: 5308873. DOI: 10.1161/ATVBAHA.116.308563. View

Fleenor B, Sindler A, Eng J, Nair D, Dodson R, Seals D . Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp Gerontol. 2012; 47(8):588-94. PMC: 3389216. DOI: 10.1016/j.exger.2012.05.004. View

Gioscia-Ryan R, Battson M, Cuevas L, Eng J, Murphy M, Seals D . Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice. J Appl Physiol (1985). 2017; 124(5):1194-1202. PMC: 6008077. DOI: 10.1152/japplphysiol.00670.2017. View

Steppan J, Bergman Y, Viegas K, Armstrong D, Tan S, Wang H . Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking-Dependent and Crosslinking-Independent Functions. J Am Heart Assoc. 2017; 6(2). PMC: 5523743. DOI: 10.1161/JAHA.116.004161. View

Tang W, Wang Z, Fan Y, Levison B, Hazen J, Donahue L . Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol. 2014; 64(18):1908-14. PMC: 4254529. DOI: 10.1016/j.jacc.2014.02.617. View

Park J, Miller M, Rhyne J, Wang Z, Hazen S . Differential effect of short-term popular diets on TMAO and other cardio-metabolic risk markers. Nutr Metab Cardiovasc Dis. 2019; 29(5):513-517. DOI: 10.1016/j.numecd.2019.02.003. View

Boutouyrie P, Tropeano A, Asmar R, Gautier I, Benetos A, Lacolley P . Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension. 2002; 39(1):10-5. DOI: 10.1161/hy0102.099031. View

10.

Li Q, Wu T, Liu R, Zhang M, Wang R . Soluble Dietary Fiber Reduces Trimethylamine Metabolism via Gut Microbiota and Co-Regulates Host AMPK Pathways. Mol Nutr Food Res. 2017; 61(12). DOI: 10.1002/mnfr.201700473. View

11.

Wang Z, Levison B, Hazen J, Donahue L, Li X, Hazen S . Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry. Anal Biochem. 2014; 455:35-40. PMC: 4167037. DOI: 10.1016/j.ab.2014.03.016. View

12.

Moldogazieva N, Mokhosoev I, Melnikova T, Porozov Y, Terentiev A . Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases. Oxid Med Cell Longev. 2019; 2019:3085756. PMC: 6710759. DOI: 10.1155/2019/3085756. View

13.

Wang Z, Bergeron N, Levison B, Li X, Chiu S, Jia X . Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women. Eur Heart J. 2018; 40(7):583-594. PMC: 6374688. DOI: 10.1093/eurheartj/ehy799. View

14.

Weisbrod R, Shiang T, Al Sayah L, Fry J, Bajpai S, Reinhart-King C . Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension. 2013; 62(6):1105-10. PMC: 3951434. DOI: 10.1161/HYPERTENSIONAHA.113.01744. View

15.

Jung S, Jandu S, Steppan J, Belkin A, An S, Pak A . Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice. Am J Physiol Heart Circ Physiol. 2013; 305(6):H803-10. PMC: 3761342. DOI: 10.1152/ajpheart.00103.2013. View

16.

Hamaya R, Ivey K, Lee D, Wang M, Li J, Franke A . Association of diet with circulating trimethylamine-N-oxide concentration. Am J Clin Nutr. 2020; 112(6):1448-1455. PMC: 7727477. DOI: 10.1093/ajcn/nqaa225. View

17.

Palombo C, Kozakova M . Arterial stiffness, atherosclerosis and cardiovascular risk: Pathophysiologic mechanisms and emerging clinical indications. Vascul Pharmacol. 2015; 77:1-7. DOI: 10.1016/j.vph.2015.11.083. View

18.

Chirinos J, Segers P, Hughes T, Townsend R . Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019; 74(9):1237-1263. PMC: 6719727. DOI: 10.1016/j.jacc.2019.07.012. View

19.

Toprak C, Sirmagul B, Yigitaslan S . Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery. Eurasian J Med. 2017; 49(3):188-192. PMC: 5665628. DOI: 10.5152/eurasianjmed.2017.17046. View

20.

Nagai M, Hoshide S, Kario K . Hypertension and dementia. Am J Hypertens. 2009; 23(2):116-24. DOI: 10.1038/ajh.2009.212. View