Neurological Pathogenesis of SARS-CoV-2 (COVID-19): from Virological Features to Clinical Symptoms

Overview

Journal Inflamm Regen

Publisher Biomed Central

Date 2021 May 8

PMID 33962695

Citations 9

Authors

Yoshitaka Kase

Hideyuki Okano

Affiliations

Soon will be listed here.

Abstract

Since the worldwide outbreak of coronavirus disease 2019 (COVID-19) in 2020, various research reports and case reports have been published. It has been found that COVID-19 causes not only respiratory disorders but also thrombosis and gastrointestinal disorders, central nervous system (CNS) disorders, and peripheral neuropathy. Compared to other disorders, there are low number of research reports and low number of summaries on COVID-19-related neural disorders. Therefore, focusing on neural disorders, we outline both basic research and clinical manifestations of COVID-19-related neural disorders.

Citing Articles

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References

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Hodge R, Bakken T, Miller J, Smith K, Barkan E, Graybuck L . Conserved cell types with divergent features in human versus mouse cortex. Nature. 2019; 573(7772):61-68. PMC: 6919571. DOI: 10.1038/s41586-019-1506-7. View

Arbour N, Day R, Newcombe J, Talbot P . Neuroinvasion by human respiratory coronaviruses. J Virol. 2000; 74(19):8913-21. PMC: 102086. DOI: 10.1128/jvi.74.19.8913-8921.2000. View

Meppiel E, Peiffer-Smadja N, Maury A, Bekri I, Delorme C, Desestret V . Neurologic manifestations associated with COVID-19: a multicentre registry. Clin Microbiol Infect. 2020; 27(3):458-466. PMC: 7661948. DOI: 10.1016/j.cmi.2020.11.005. View

Romero-Sanchez C, Diaz-Maroto I, Fernandez-Diaz E, Sanchez-Larsen A, Layos-Romero A, Garcia-Garcia J . Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology. 2020; 95(8):e1060-e1070. PMC: 7668545. DOI: 10.1212/WNL.0000000000009937. View

Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J . A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020; 94:55-58. PMC: 7195378. DOI: 10.1016/j.ijid.2020.03.062. View

Kase Y, Okano H . Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders. Inflamm Regen. 2020; 40:32. PMC: 7485212. DOI: 10.1186/s41232-020-00143-6. View

Pellegrini L, Albecka A, Mallery D, Kellner M, Paul D, Carter A . SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Cell Stem Cell. 2020; 27(6):951-961.e5. PMC: 7553118. DOI: 10.1016/j.stem.2020.10.001. View

HAMRE D, PROCKNOW J . A new virus isolated from the human respiratory tract. Proc Soc Exp Biol Med. 1966; 121(1):190-3. DOI: 10.3181/00379727-121-30734. View

10.

Nakagawa S, Miyazawa T . Genome evolution of SARS-CoV-2 and its virological characteristics. Inflamm Regen. 2020; 40:17. PMC: 7415347. DOI: 10.1186/s41232-020-00126-7. View

11.

Ramani A, Muller L, Ostermann P, Gabriel E, Abida-Islam P, Muller-Schiffmann A . SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO J. 2020; 39(20):e106230. PMC: 7560208. DOI: 10.15252/embj.2020106230. View

12.

Li Y, Bai W, Hashikawa T . The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020; 92(6):552-555. PMC: 7228394. DOI: 10.1002/jmv.25728. View

13.

Arbour N, Cote G, Lachance C, Tardieu M, Cashman N, Talbot P . Acute and persistent infection of human neural cell lines by human coronavirus OC43. J Virol. 1999; 73(4):3338-50. PMC: 104098. DOI: 10.1128/JVI.73.4.3338-3350.1999. View

14.

Cowley J, Dimmock C, Spann K, Walker P . Gill-associated virus of Penaeus monodon prawns: an invertebrate virus with ORF1a and ORF1b genes related to arteri- and coronaviruses. J Gen Virol. 2000; 81(Pt 6):1473-84. DOI: 10.1099/0022-1317-81-6-1473. View

15.

Tiwari S, Wang S, Smith D, Carlin A, Rana T . Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids. Stem Cell Reports. 2021; 16(3):437-445. PMC: 7879814. DOI: 10.1016/j.stemcr.2021.02.005. View

16.

Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B . COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features. Radiology. 2020; 296(2):E119-E120. PMC: 7233386. DOI: 10.1148/radiol.2020201187. View

17.

Muller M, Meyer B, Corman V, Al-Masri M, Turkestani A, Ritz D . Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis. 2015; 15(5):559-64. PMC: 7185864. DOI: 10.1016/S1473-3099(15)70090-3. View

18.

Andersen K, Rambaut A, Lipkin W, Holmes E, Garry R . The proximal origin of SARS-CoV-2. Nat Med. 2020; 26(4):450-452. PMC: 7095063. DOI: 10.1038/s41591-020-0820-9. View

19.

Netland J, Meyerholz D, Moore S, Cassell M, Perlman S . Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol. 2008; 82(15):7264-75. PMC: 2493326. DOI: 10.1128/JVI.00737-08. View

20.

Lechien J, Chiesa-Estomba C, De Siati D, Horoi M, Le Bon S, Rodriguez A . Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020; 277(8):2251-2261. PMC: 7134551. DOI: 10.1007/s00405-020-05965-1. View