Role of Microbes in the Pathogenesis of Neuropsychiatric Disorders

Overview

Journal Front Neuroendocrinol

Specialty Endocrinology

Date 2021 May 6

PMID 33957173

Citations 10

Authors

Aranyak Goswami

Frank R Wendt

Gita A Pathak

Daniel S Tylee

Flavio De Angelis

Antonella De Lillo

Renato Polimanti

Affiliations

Soon will be listed here.

Abstract

Microbes inhabit different anatomical sites of the human body including oral cavity, gut, and skin. A growing literature highlights how microbiome variation is associated with human health and disease. There is strong evidence of bidirectional communication between gut and brain mediated by neurotransmitters and microbial metabolites. Here, we review the potential involvement of microbes residing in the gut and in other body sites in the pathogenesis of eight neuropsychiatric disorders, discussing findings from animal and human studies. The data reported provide a comprehensive overview of the current state of the microbiome research in neuropsychiatry, including hypotheses about the mechanisms underlying the associations reported and the translational potential of probiotics and prebiotics.

Citing Articles

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