Trehalose/sodium Hyaluronate Eye Drops in Post-cataract Ocular Surface Disorders

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 2021 May 6

PMID 33956256

Citations 10

Authors

Carlo Cagini

Giovanni Torroni

Marco Mariniello

Giampiero Di Lascio

Gianluca Martone

Angelo Balestrazzi

Affiliations

Soon will be listed here.

Abstract

Purpose: Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing cataract surgery.

Methods: Patients with healthy ocular surface, subclinical, or mild dry eye were enrolled. Tear breakup time (TBUT), Schirmer test, dry eye symptoms, corneal fluorescein staining (CFS), and ocular surface disease (OSDI) evaluation were performed pre-operatively and at two and four weeks after surgery. Patients were assigned to receive trehalose/sodium hyaluronate eye drops b.i.d (Group A), or 0.9% unpreserved sodium chloride eye drops b.i.d for 4 weeks (Group B).

Results: One hundred and thirty-five patients were randomised, 66 patients in Group A (73.2 ± 4.5 years) and 69 patients in Group B (74.3 ± 3.8 years), 60.8% females. Fifteen patients (8 Group A) were lost at follow-up. Pre-operatively, no between-group differences were observed, and TBUT increased in Group A between the pre-operative and 2 and 4 week evaluations and was higher in group A than in Group B at 4 weeks. Schirmer test and CFS showed an improvement only in Group A four weeks post-operatively. In Group A an improvement was observed after two and four weeks in foreign body and puncture sensation, whilst a difference in blinking discomfort was observed after four weeks. In Group B we observed an improvement in puncture sensation two and four weeks after surgery. Mean OSDI scores differences between the two groups were significant at four weeks.

Conclusions: Trehalose/sodium hyaluronate eye drops were effective in reducing signs and symptoms of dry eye and improving tear film stability.

Citing Articles

Patient Experience with ABBV-444, a Proof-of-Concept Study for a Novel Artificial Tear with Trehalose and Sodium Hyaluronate for Dry Eye Symptoms.

Hom M, Ladhani O, Zhang Z, Liu H, Sonparote S, Dancey C Clin Optom (Auckl). 2025; 17:37-45.

PMID: 39963316 PMC: 11830937. DOI: 10.2147/OPTO.S490732.

Assessing the therapeutic role of trehalose and hyaluronic acid: implications for patient care.

Gawash A, Simonetti A, Lo D, Shamilov D, Kumar A, Wong J Int Ophthalmol. 2024; 44(1):398.

PMID: 39352586 DOI: 10.1007/s10792-024-03308-1.

Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery.

Li J, Zhao J, Guo Z, Xiao C, Liu X World J Diabetes. 2024; 15(6):1234-1241.

PMID: 38983819 PMC: 11229957. DOI: 10.4239/wjd.v15.i6.1234.

Preventing and Managing Iatrogenic Dry Eye Disease during the Entire Surgical Pathway: A Study Focusing on Patients Undergoing Cataract Surgery.

Giannaccare G, Barabino S, Di Zazzo A, Villani E J Clin Med. 2024; 13(3).

PMID: 38337442 PMC: 10856703. DOI: 10.3390/jcm13030748.

Trehalose and Dry Eye Disease: A Comprehensive Systematic Review of Randomized Controlled Trials.

Ballesteros-Sanchez A, Martinez-Perez C, Alvarez-Peregrina C, Sanchez-Tena M, De-Hita-Cantalejo C, Sanchez-Gonzalez M J Clin Med. 2023; 12(23).

PMID: 38068353 PMC: 10707449. DOI: 10.3390/jcm12237301.

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