A Dual-target Molecular Mechanism of Pyrethrum Repellency Against Mosquitoes

Overview

Journal Nat Commun

Specialty Biology

Date 2021 May 6

PMID 33953207

Citations 14

Authors

Feng Liu

Qiang Wang

Peng Xu

Felipe Andreazza

Wilson R Valbon

Elizabeth Bandason

Mengli Chen

Ru Yan

Bo Feng

Leticia B Smith

Jeffrey G Scott

Genki Takamatsu

Makoto Ihara

Kazuhiko Matsuda

James Klimavicz

Joel Coats

Eugenio E Oliveira

Yuzhe Du

Ke Dong

Affiliations

Soon will be listed here.

Abstract

Pyrethrum extracts from flower heads of Chrysanthemum spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms of its insecticidal action are known, the molecular basis of pyrethrum repellency remains a mystery. In this study, we find that the principal components of pyrethrum, pyrethrins, and a minor component, (E)-β-farnesene (EBF), each activate a specific type of olfactory receptor neurons in Aedes aegypti mosquitoes. We identify Ae. aegypti odorant receptor 31 (AaOr31) as a cognate Or for EBF and find that Or31-mediated repellency is significantly synergized by pyrethrin-induced activation of voltage-gated sodium channels. Thus, pyrethrum exerts spatial repellency through a novel, dual-target mechanism. Elucidation of this two-target mechanism may have potential implications in the design and development of a new generation of synthetic repellents against major mosquito vectors of infectious diseases.

Citing Articles

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