Interoceptive Attention Regulation in Ehlers-Danlos Syndromes: Associations Between Pain and Psychiatric Symptom Severity

Overview

Journal Transl Behav Med

Publisher Oxford University Press

Specialties General Medicine
Public Health
Social Sciences

Date 2021 May 5

PMID 33949672

Citations 2

Authors

Madison Niermeyer

Douglas Ball

Michael Green

Bradley Jensen

Laura Pace

Robert Shingleton

Bradley Fawver

Stephen K Trapp

Affiliations

Soon will be listed here.

Abstract

Conclusions: The current project replicated recent findings that pain, anxiety, and depression are common in individuals with EDS+. The ability to focus and control somatic attention appears to be protective and a potential target for interventions in EDS+.

Citing Articles

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Willich L, Bohner L, Koppe J, Jackowski J, Hanisch M, Oelerich O Orphanet J Rare Dis. 2023; 18(1):294.

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References

Mehling W . Differentiating attention styles and regulatory aspects of self-reported interoceptive sensibility. Philos Trans R Soc Lond B Biol Sci. 2017; 371(1708). PMC: 5062101. DOI: 10.1098/rstb.2016.0013. View

Bloom L, Byers P, Francomano C, Tinkle B, Malfait F . The international consortium on the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2017; 175(1):5-7. DOI: 10.1002/ajmg.c.31547. View

Raj V, Opie M, Arnold A . Cognitive and psychological issues in postural tachycardia syndrome. Auton Neurosci. 2018; 215:46-55. PMC: 6160364. DOI: 10.1016/j.autneu.2018.03.004. View

Hershenfeld S, Wasim S, McNiven V, Parikh M, Majewski P, Faghfoury H . Psychiatric disorders in Ehlers-Danlos syndrome are frequent, diverse and strongly associated with pain. Rheumatol Int. 2015; 36(3):341-8. DOI: 10.1007/s00296-015-3375-1. View

Kerns R, Turk D, Rudy T . The West Haven-Yale Multidimensional Pain Inventory (WHYMPI). Pain. 1985; 23(4):345-356. DOI: 10.1016/0304-3959(85)90004-1. View

Fogel S . Surgical failures: is it the surgeon or the patient? The all too often missed diagnosis of Ehlers-Danlos syndrome. Am Surg. 2013; 79(6):608-13. View

Price C, Thompson E, Crowell S, Pike K . Longitudinal effects of interoceptive awareness training through mindful awareness in body-oriented therapy (MABT) as an adjunct to women's substance use disorder treatment: A randomized controlled trial. Drug Alcohol Depend. 2019; 198:140-149. PMC: 6467707. DOI: 10.1016/j.drugalcdep.2019.02.012. View

Owens A, Low D, Iodice V, Critchley H, Mathias C . The genesis and presentation of anxiety in disorders of autonomic overexcitation. Auton Neurosci. 2016; 203:81-87. DOI: 10.1016/j.autneu.2016.10.004. View

Tunks E, Crook J, Weir R . Epidemiology of chronic pain with psychological comorbidity: prevalence, risk, course, and prognosis. Can J Psychiatry. 2008; 53(4):224-34. DOI: 10.1177/070674370805300403. View

10.

Khoury B, Lecomte T, Fortin G, Masse M, Therien P, Bouchard V . Mindfulness-based therapy: a comprehensive meta-analysis. Clin Psychol Rev. 2013; 33(6):763-71. DOI: 10.1016/j.cpr.2013.05.005. View

11.

Spitzer R, Kroenke K, Williams J, Lowe B . A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006; 166(10):1092-7. DOI: 10.1001/archinte.166.10.1092. View

12.

Hayes A, Rockwood N . Regression-based statistical mediation and moderation analysis in clinical research: Observations, recommendations, and implementation. Behav Res Ther. 2016; 98:39-57. DOI: 10.1016/j.brat.2016.11.001. View

13.

Mehling W, Price C, Daubenmier J, Acree M, Bartmess E, Stewart A . The Multidimensional Assessment of Interoceptive Awareness (MAIA). PLoS One. 2012; 7(11):e48230. PMC: 3486814. DOI: 10.1371/journal.pone.0048230. View

14.

Farb N, Daubenmier J, Price C, Gard T, Kerr C, Dunn B . Interoception, contemplative practice, and health. Front Psychol. 2015; 6:763. PMC: 4460802. DOI: 10.3389/fpsyg.2015.00763. View

15.

Reilly C . Transdisciplinary approach: an atypical strategy for improving outcomes in rehabilitative and long-term acute care settings. Rehabil Nurs. 2002; 26(6):216-20, 244. DOI: 10.1002/j.2048-7940.2001.tb01958.x. View

16.

Berglund B, Anne-Cathrine M, Randers I . Dignity not fully upheld when seeking health care: experiences expressed by individuals suffering from Ehlers-Danlos syndrome. Disabil Rehabil. 2009; 32(1):1-7. DOI: 10.3109/09638280903178407. View

17.

Mehling W, Chesney M, Metzler T, Goldstein L, Maguen S, Geronimo C . A 12-week integrative exercise program improves self-reported mindfulness and interoceptive awareness in war veterans with posttraumatic stress symptoms. J Clin Psychol. 2017; 74(4):554-565. DOI: 10.1002/jclp.22549. View

18.

Mallorqui-Bague N, Garfinkel S, Engels M, Eccles J, Pailhez G, Bulbena A . Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility. Front Psychol. 2014; 5:1162. PMC: 4196473. DOI: 10.3389/fpsyg.2014.01162. View

19.

Tarricone I, Stivanello E, Poggi F, Castorini V, Marseglia M, Fantini M . Ethnic variation in the prevalence of depression and anxiety in primary care: a systematic review and meta-analysis. Psychiatry Res. 2011; 195(3):91-106. DOI: 10.1016/j.psychres.2011.05.020. View

20.

Knoerl R, Smith E, Weisberg J . Chronic Pain and Cognitive Behavioral Therapy: An Integrative Review. West J Nurs Res. 2015; 38(5):596-628. DOI: 10.1177/0193945915615869. View