Synthesis of Asymmetrical Diaminobis(alkoxo)-bisphenol Compounds and Their C-symmetrical Mono-ligated Titanium(iv) Complexes As Highly Stable Highly Active Antitumor Compounds

Overview

Journal Dalton Trans

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 May 5

PMID 33949509

Citations 3

Authors

Gilad Nahari

Edit Y Tshuva

Affiliations

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Abstract

Asymmetrical 2,2'-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding. Different substitutions on the two aromatic rings enabled fine-tuning of the complex properties, giving enhanced solubility, high anticancer activity (IC < 4 μM), and significant hydrolytic stability.

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