Association Between Vitamin D Receptor (VDR) and Vitamin D Binding Protein (VDBP) Genes Polymorphisms to Endometriosis Susceptibility in Iranian Women

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2021 May 5

PMID 33948927

Citations 3

Authors

Mohammad Jafari

Sepideh Khodaverdi

Maryam Sadri

Zahra Moradi

Tahereh Mohammadi

Sahel Heidari

ZHima Akhavan Sales

Ali-Akbar Delbandi

Affiliations

Soon will be listed here.

Abstract

Endometriosis is a chronic inflammatory disease that has been reported to be associated with immune system dysfunction. On the other hand, the effect of Vitamin D as an immune modulator and its relation with several autoimmune and inflammatory diseases has been previously investigated. Moreover, several studies have reported the polymorphisms of VDR and VDBP genes can change the functions of these molecules. Therefore, these polymorphisms may be influential on endometriosis pathogenesis. In this study, we aimed at evaluating the association between VDR gene (FokI (F/f), BsmI (B/b), ApaI (A/a), TaqI (T/t)), and VDBP gene (GC*1S, GC*1F, and GC*2) polymorphisms with endometriosis in Iranian women population. This case-control study was performed on 120 women with endometriosis and 110 healthy women. ARMS-PCR and PCR-RFLP methods were used to inspect polymorphisms in VDR and VDBP genes, respectively. Based on the results, there was no statistically significant difference between the cases with endometriosis and control subjects in terms of genotypes and allele frequencies of VDR and VDBP gene polymorphisms. These data suggest that VDR and VDBP gene polymorphisms may have no role in endometriosis susceptibility in Iranian women.

Citing Articles

Vitamin D and Endometriosis: Is There a Mechanistic Link?.

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Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis.

Farhangnia P, Noormohammadi M, Delbandi A Reprod Health. 2024; 21(1):61.

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Vitamin D-The Iceberg in Endometriosis-Review and Meta-Analysis.

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