Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 May 5

PMID 33946994

Citations 7

Authors

Marcela Julio-Pieper

Alejandra Lopez-Aguilera

Johana Eyzaguirre-Velasquez

Loreto Olavarria-Ramirez

Claudia Ibacache-Quiroga

Javier A Bravo

Gonzalo Cruz

Affiliations

Soon will be listed here.

Abstract

The gastrointestinal lumen is a rich source of eukaryotic and prokaryotic viruses which, together with bacteria, fungi and other microorganisms comprise the gut microbiota. Pathogenic viruses inhabiting this niche have the potential to induce local as well as systemic complications; among them, the viral ability to disrupt the mucosal barrier is one mechanism associated with the promotion of diarrhea and tissue invasion. This review gathers recent evidence showing the contributing effects of diet, gut microbiota and the enteric nervous system to either support or impair the mucosal barrier in the context of viral attack.

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