Inhibition of Passive Cutaneous Anaphylaxis by Several Histamine (H1) and Serotonin Antagonists in the Rat
Overview
Overview
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Drugs of the pizotifen type (pizotifen, cyproheptadine), possessing high H1-antihistamine and high antiserotonin activities in animal experiments, exert potent inhibitory actions on the passive cutaneous anaphylaxis (PCA) reaction in the rat. The drug pipethiadene, a 4,9-dihydrothieno(2,3-c)-2-benzothiepin derivative also belongs to this group. Selective histamine H1-antagonists alone are unable to cause pronounced reduction of the intensity of the PCA reaction in the rat, but in local reactions induced in rats by compound 48/80, histamine H1-receptors seem to play major role.
References
1.
Romer D, WEIDMANN H
. [Pharmacological studies on the new antihistaminic Tavegil]. Med Welt. 1966; 51:2791-4.
View
2.
Mota I
. THE MECHANISM OF ANAPHYLAXIS. I. PRODUCTION AND BIOLOGICAL PROPERTIES OF 'MAST CELL SENSITIZING' ANTIBODY. Immunology. 1964; 7:681-99.
PMC: 1423401.
View
3.
Martin U, Romer D
. The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene. Arzneimittelforschung. 1978; 28(5):770-82.
View
4.
METYS J, METYSOVA J
. [Derivative of 4,9-dihydrothieno(2,3-b)benzo(e)thiepine--a new type of effective antihistaminic]. Acta Biol Med Ger. 1965; 15(6):871-3.
View
5.
Speight T, Avery G
. Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches. Drugs. 1972; 3(3):159-203.
DOI: 10.2165/00003495-197203030-00002.
View