Mouse Middle-ear Forward and Reverse Acoustics

Overview

Journal J Acoust Soc Am

Publisher American Institute of Physics

Specialty Otorhinolaryngology

Date 2021 May 4

PMID 33940924

Citations 4

Authors

Hamid Motallebzadeh

Sunil Puria

Affiliations

Soon will be listed here.

Abstract

The mouse is an important animal model for hearing science. However, our knowledge of the relationship between mouse middle-ear (ME) anatomy and function is limited. The ME not only transmits sound to the cochlea in the forward direction, it also transmits otoacoustic emissions generated in the cochlea to the ear canal (EC) in the reverse direction. Due to experimental limitations, a complete characterization of the mouse ME has not been possible. A fully coupled finite-element model of the mouse EC, ME, and cochlea was developed and calibrated against experimental measurements. Impedances of the EC, ME, and cochlea were calculated, alongside pressure transfer functions for the forward, reverse, and round-trip directions. The effects on sound transmission of anatomical changes such as removing the ME cavity, pars flaccida, and mallear orbicular apophysis were also calculated. Surprisingly, below 10 kHz, the ME cavity, eardrum, and stapes annular ligament were found to significantly affect the cochlear input impedance, which is a result of acoustic coupling through the round window. The orbicular apophysis increases the delay of the transmission line formed by the flexible malleus, incus, and stapes, and improves the forward sound-transmission characteristics in the frequency region of 7-30 kHz.

Citing Articles

From Simulations to Inference: Using Machine Learning to Tune Patient-Specific Finite-Element Models of the Middle Ear Towards Objective Diagnosis.

Motallebzadeh H, Deistler M, Schonleitner F, Macke J, Puria S bioRxiv. 2024; .

PMID: 39464130 PMC: 11507950. DOI: 10.1101/2024.10.15.618553.

The influence of tympanic-membrane orientation on acoustic ear-canal quantities: A finite-element analysis.

Norgaard K, Motallebzadeh H, Puria S J Acoust Soc Am. 2024; 155(4):2769-2785.

PMID: 38662609 PMC: 11052631. DOI: 10.1121/10.0025768.

Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears.

Golabbakhsh M, Wang X, MacDougall D, Farrell J, Landry T, Funnell W J Assoc Res Otolaryngol. 2023; 24(3):339-363.

PMID: 37165211 PMC: 10335995. DOI: 10.1007/s10162-023-00899-x.

Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model.

Motallebzadeh H, Puria S J Acoust Soc Am. 2022; 152(5):2769.

PMID: 36456266 PMC: 9643045. DOI: 10.1121/10.0014901.

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