Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2021 May 3

PMID 33935650

Citations 8

Authors

Xi-Le Zhang

Xiao-Guang Zhang

Yan-Ran Huang

Yan-Yan Zheng

Peng-Jie Ying

Xiao-Jie Zhang

Xiao Lu

Yi-Jing Wang

Guo-Qing Zheng

Affiliations

Soon will be listed here.

Abstract

Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by searching PubMed, EMBASE, and Web of Science from inception to August 1, 2020. There are about 141 comparisons, involving 5,200 animals, that examined the effect of stem cell transplantation on neurological function and infarct volume as primary outcome measures in animal models for stroke. Stem cell-based therapy can improve both neurological function (effect size, -3.37; 95% confidence interval, -3.83 to -2.90) and infarct volume (effect size, -11.37; 95% confidence interval, -12.89 to -9.85) compared with controls. These results suggest that stem cell therapy could improve neurological function deficits and infarct volume, exerting potential neuroprotective effect for experimental ischemic stroke, but further clinical studies are still needed.

Citing Articles

Brain repair mechanisms after cell therapy for stroke.

Rust R, Nih L, Liberale L, Yin H, El Amki M, Ong L Brain. 2024; 147(10):3286-3305.

PMID: 38916992 PMC: 11449145. DOI: 10.1093/brain/awae204.

Estimation of the Ischemic Lesion in the Experimental Stroke Studies Using Magnetic Resonance Imaging (Review).

Namestnikova D, Cherkashova E, Gumin I, Chekhonin V, Yarygin K, Gubskiy I Bull Exp Biol Med. 2024; 176(5):649-657.

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Comparative study of the efficacy of intra-arterial and intravenous transplantation of human induced pluripotent stem cells-derived neural progenitor cells in experimental stroke.

Cherkashova E, Namestnikova D, Leonov G, Gubskiy I, Sukhinich K, Melnikov P PeerJ. 2023; 11:e16358.

PMID: 38025691 PMC: 10640846. DOI: 10.7717/peerj.16358.

Targeting Neurogenesis in Seeking Novel Treatments for Ischemic Stroke.

Nagase T, Kin K, Yasuhara T Biomedicines. 2023; 11(10).

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A review and meta-analysis of stem cell therapies in stroke patients: effectiveness and safety evaluation.

Hovhannisyan L, Khachatryan S, Khamperyan A, Matinyan S Neurol Sci. 2023; 45(1):65-74.

PMID: 37733251 PMC: 10761518. DOI: 10.1007/s10072-023-07032-z.

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