The Implications of Histamine Metabolism and Signaling in Renal Function

Overview

Journal Physiol Rep

Specialty Physiology

Date 2021 May 1

PMID 33932106

Citations 8

Authors

Anastasia V Sudarikova

Mikhail V Fomin

Irina A Yankelevich

Daria V Ilatovskaya

Affiliations

Soon will be listed here.

Abstract

Inflammation is an essential part of the immune response; it has been found to be central to the disruption of kidney function in acute kidney injury, diabetic nephropathy, hypertension, and other renal conditions. One of the well-known mediators of the inflammatory response is histamine. Histamine receptors are expressed throughout different tissues, including the kidney, and their inhibition has proven to be a viable strategy for the treatment of many inflammation-associated diseases. Here, we provide an overview of the current knowledge regarding the role of histamine and its metabolism in the kidney. Establishing the importance of histamine signaling for kidney function will enable new approaches for the treatment of kidney diseases associated with inflammation.

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