A Systematic Review of Toll-like Receptors in Endometriosis

Overview

Journal Arch Gynecol Obstet

Specialty Gynecology & Obstetrics

Date 2021 Apr 30

PMID 33928453

Citations 4

Authors

Bruna Cestari de Azevedo

Fernanda Mansur

Sergio Podgaec

Affiliations

Soon will be listed here.

Abstract

Introduction: The pathogen-associated molecular patterns and the danger-associated molecular patterns are possibly responsible for the activation of the inflammatory process in endometriosis through the activation of toll-like receptors (TLRs).

Objective: The aim of this systematic review was to critically analyze the findings of published articles on TLRs in endometriosis.

Methods: The keywords used were "endometriosis" and "toll-like" and the search was performed in Pubmed, Scielo and Lilacs databases. This study followed the PRISMA guidelines and the risk of bias of articles was conducted by Newcastle-Ottawa scale (NOS).

Results: Overall, the studies analyzed in this review point toward an increased expression of TLRs two, four and nine in women with endometriosis. Among all TLRs, TLR4 was the most cited receptor.

Conclusion: Despite the evidence demonstrating elevated TLR levels in endometriosis, the relationship with the disease is still unclear and needs to be clarified in further studies about innate immune response.

Citing Articles

Expression of mRNA-TLR-5 Gene in Patients with Endometriosis using Real-time PCR in Tehran, Iran.

Raghibi M, Raghibi M, Morovvati A, Shakib P, Aflatoonian R, Dirbaiyan A Recent Adv Antiinfect Drug Discov. 2024; 19(4):300-306.

PMID: 38213148 DOI: 10.2174/0127724344251369231212061409.

Pattern-recognition receptors in endometriosis: A narrative review.

Guo B, Chen J, Zhang J, Fang Y, Liu X, Zhang J Front Immunol. 2023; 14:1161606.

PMID: 37033937 PMC: 10076794. DOI: 10.3389/fimmu.2023.1161606.

Bushen Wenyang Huayu Decoction Targets TLR4/NF-B Mediated Autophagy to Treat Endometriosis Effectively.

Li Y, Meng X, Fu X, An M, Liu H, Ma Y Evid Based Complement Alternat Med. 2022; 2022:4263417.

PMID: 36437825 PMC: 9699773. DOI: 10.1155/2022/4263417.

Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells.

Kusama K, Satoyoshi A, Azumi M, Yoshie M, Kojima J, Mizuno Y Front Endocrinol (Lausanne). 2022; 13:966455.

PMID: 36093086 PMC: 9448891. DOI: 10.3389/fendo.2022.966455.

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