Transcranial Magnetic Resonance-Guided Focused Ultrasound in X-Linked Dystonia-Parkinsonism

Overview

Journal Life (Basel)

Specialty Biology

Date 2021 Apr 30

PMID 33925939

Citations 7

Authors

Roland Dominic G Jamora

Wei-Chieh Chang

Takaomi Taira

Affiliations

Soon will be listed here.

Abstract

X-linked dystonia-parkinsonism (XDP) is a neurodegenerative condition found among males with maternal ancestry from Panay Island, Philippines. The treatment options are limited. We report on our experience of three XDP patients who underwent transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) pallidothalamic tractotomy. The three patients were all genetically confirmed XDP, with a mean XDP-Movement Disorder Society of the Philippines (MDSP) Scale score of 68.7/200. All patients were on stable doses of their oral medications and their last botulinum toxin injection was 12 months prior to study. Two patients complained of moderate to severe arm pain 2-7 months after the procedure. There was an overall improvement in the XDP-MDSP Scale score of 36.2% (18.7 vs. 15) at 6 months and 30.1% (68.7 vs. 45.5) at 1 year. Notably, there was worsening of the nonmotor subscale (part IIIB, nonbehavioral aspect) by 350% at 1 year. While these numbers are encouraging, there is a need to do a larger study on the safety and efficacy of tcMRgFUS on XDP.

Citing Articles

Magnetic resonance-guided focused ultrasound in dystonia: a scoping review.

Guinal S, Jamora R, Khu K, Aguilar J Neurol Sci. 2024; 46(3):1121-1130.

PMID: 39562491 DOI: 10.1007/s10072-024-07882-1.

Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.

Lefaucheur J, Moro E, Shirota Y, Ugawa Y, Grippe T, Chen R Clin Neurophysiol. 2024; 164:57-99.

PMID: 38852434 PMC: 11418354. DOI: 10.1016/j.clinph.2024.05.007.

MRI-Guided Focused Ultrasound for the Treatment of Dystonia: A Narrative Review.

Momin S, Aquilina K, Bulstrode H, Taira T, Kalia S, Natalwala A Cureus. 2024; 16(2):e54284.

PMID: 38500932 PMC: 10945285. DOI: 10.7759/cureus.54284.

The Optimal Targeting for Focused Ultrasound Thalamotomy Differs between Dystonic and Essential Tremor: A 12-Month Prospective Pilot Study.

Andreasi N, Braccia A, Levi V, Rinaldo S, Ghielmetti F, Cilia R Mov Disord Clin Pract. 2024; 11(1):69-75.

PMID: 38291839 PMC: 10828621. DOI: 10.1002/mdc3.13911.

Transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for patients with X-linked dystonia-parkinsonism: a study protocol.

Jamora R, Khu K, Sy M, Pascual J, Legaspi G, Aguilar J BMC Neurol. 2023; 23(1):306.

PMID: 37596524 PMC: 10436542. DOI: 10.1186/s12883-023-03344-x.

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