The Role of Lung Colonization in Connective Tissue Disease-Associated Interstitial Lung Disease

Overview

Journal Microorganisms

Specialty Microbiology

Date 2021 Apr 30

PMID 33925354

Citations 7

Authors

Alberto Ricci

Alessandra Pagliuca

Morgana Vermi

Dario Pizzirusso

Marta Innammorato

Raffaele Sglavo

Francesco Scarso

Simonetta Salemi

Bruno Lagana

Roberta Di Rosa

Michela DAscanio

Affiliations

Soon will be listed here.

Abstract

Connective tissue diseases (CTDs) may frequently manifest with interstitial lung disease (ILD), which may severely impair quality and expectation of life. CTD-ILD generally has a chronic clinical course, with possible acute exacerbations. Although several lines of evidence indicate a relevant role of infections in the acute exacerbations of CTD-ILD, little information is available regarding the prevalence of infections in chronic CTD-ILD and their possible role in the clinical course. The aim of the present retrospective study was the identification of lung microbial colonization in broncho-alveolar lavage from patients affected by stable CTD-ILD with radiologically defined lung involvement. We demonstrated that 22.7% of patients with CTD-ILD display microbial colonization by , and non-tuberculous mycobacteria. Moreover, these patients display a major radiologic lung involvement, with higher impairment in lung function tests confirmed in a multivariate logistic regression analysis. Overall, the present study provides new information on lung colonization during CTD-ILD and its possible relationship with lung disease progression and severity.

Citing Articles

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