The Roles of IL-17, IL-21, and IL-23 in the Infection and Gastrointestinal Inflammation: A Review

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2021 Apr 30

PMID 33924897

Citations 15

Authors

Astri Dewayani

Kartika Afrida Fauzia

Ricky Indra Alfaray

Langgeng Agung Waskito

Dalla Doohan

Yudith Annisa Ayu Rezkitha

Abdurachman Abdurachman

Takashi Kobayashi

Reny Itishom

Yoshio Yamaoka

Muhammad Miftahussurur

Affiliations

Soon will be listed here.

Abstract

Although millions of people have been infected by (), only a small proportion of infected individuals will develop adverse outcomes, ranging from chronic gastritis to gastric cancer. Advanced development of the disease has been well-linked with chronic inflammation, which is significantly impacted by the adaptive and humoral immunity response. From the perspective of cellular immunity, this review aims to clarify the intricate axis between IL-17, IL-21, and IL-23 in -related diseases and the pathogenesis of inflammatory gastrointestinal diseases. CD4 helper T (Th)-17 cells, with the hallmark pleiotropic cytokine IL-17, can affect antimicrobial activity and the pathogenic immune response in the gut environment. These circumstances cannot be separated, as the existence of affiliated cytokines, including IL-21 and IL-23, help maintain Th17 and accommodate humoral immune cells. Comprehensive understanding of the dynamic interaction between molecular host responses in -related diseases and the inflammation process may facilitate further development of immune-based therapy.

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