Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Apr 30

PMID 33924646

Citations 3

Authors

Samia D Ellias

Ellen L Larson

Timucin Taner

Scott L Nyberg

Affiliations

Soon will be listed here.

Abstract

Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.

Citing Articles

Factors associated with operational tolerance after liver transplantation: a single center retrospective study.

Park S, Choi G Korean J Transplant. 2023; 37(4):286-292.

PMID: 38153255 PMC: 10772272. DOI: 10.4285/kjt.23.0066.

Role of Kupffer cells in tolerance induction after liver transplantation.

Zheng W, Yang L, Jiang S, Chen M, Li J, Liu Z Front Cell Dev Biol. 2023; 11:1179077.

PMID: 37601106 PMC: 10435084. DOI: 10.3389/fcell.2023.1179077.

Cell transplantation-based regenerative medicine in liver diseases.

Cardinale V, Lanthier N, Baptista P, Carpino G, Carnevale G, Orlando G Stem Cell Reports. 2023; 18(8):1555-1572.

PMID: 37557073 PMC: 10444572. DOI: 10.1016/j.stemcr.2023.06.005.

References

Wake K . "Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A. Am J Anat. 1971; 132(4):429-62. DOI: 10.1002/aja.1001320404. View

Gordon J, Ma Y, Churchman L, Gordon S, Dawicki W . Regulatory dendritic cells for immunotherapy in immunologic diseases. Front Immunol. 2014; 5:7. PMC: 3907717. DOI: 10.3389/fimmu.2014.00007. View

Coppel R, Mackay I, Bass N, Ansari A, Gershwin M . The immunobiology of bile and biliary epithelium. Hepatology. 1999; 30(2):351-7. DOI: 10.1002/hep.510300218. View

Joyce D, Fujino M, Morita M, Araki R, Fung J, Qian S . Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response. Stem Cell Res. 2018; 29:32-41. DOI: 10.1016/j.scr.2018.03.009. View

Niu J, Wang Y, Liu B, Yao Y . Mesenchymal stem cells prolong the survival of orthotopic liver transplants by regulating the expression of TGF-β1. Turk J Gastroenterol. 2018; 29(5):601-609. PMC: 6284621. DOI: 10.5152/tjg.2018.17395. View

Calne R, Sells R, Pena J, Davis D, Millard P, HERBERTSON B . Induction of immunological tolerance by porcine liver allografts. Nature. 1969; 223(5205):472-6. DOI: 10.1038/223472a0. View

Sato K, Yamashita N, Baba M, Matsuyama T . Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood. 2003; 101(9):3581-9. DOI: 10.1182/blood-2002-09-2712. View

Shetty S, Lalor P, Adams D . Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity. Nat Rev Gastroenterol Hepatol. 2018; 15(9):555-567. PMC: 7096836. DOI: 10.1038/s41575-018-0020-y. View

Lee K, Nguyen V, Lee K, Kang S, Tang Q . Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy. Am J Transplant. 2013; 14(1):27-38. PMC: 5262439. DOI: 10.1111/ajt.12509. View

10.

Abrol N, Jadlowiec C, Taner T . Revisiting the liver's role in transplant alloimmunity. World J Gastroenterol. 2019; 25(25):3123-3135. PMC: 6626728. DOI: 10.3748/wjg.v25.i25.3123. View

11.

Mehal W, Azzaroli F, Crispe I . Immunology of the healthy liver: old questions and new insights. Gastroenterology. 2001; 120(1):250-60. DOI: 10.1053/gast.2001.20947. View

12.

Rastellini C, Lu L, Ricordi C, Starzl T, Rao A, Thomson A . Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation. 1995; 60(11):1366-70. PMC: 2966312. View

13.

Stegall M, Chedid M, Cornell L . The role of complement in antibody-mediated rejection in kidney transplantation. Nat Rev Nephrol. 2012; 8(11):670-8. DOI: 10.1038/nrneph.2012.212. View

14.

Walker L, Sansom D . The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat Rev Immunol. 2011; 11(12):852-63. DOI: 10.1038/nri3108. View

15.

Zhou X, Bailey-Bucktrout S, Jeker L, Penaranda C, Martinez-Llordella M, Ashby M . Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009; 10(9):1000-7. PMC: 2729804. DOI: 10.1038/ni.1774. View

16.

Moroso V, Famili F, Papazian N, Cupedo T, van der Laan L, Kazemier G . NK cells can generate from precursors in the adult human liver. Eur J Immunol. 2011; 41(11):3340-50. DOI: 10.1002/eji.201141760. View

17.

Zhang W, Ge W, Li C, You S, Liao L, Han Q . Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev. 2004; 13(3):263-71. DOI: 10.1089/154732804323099190. View

18.

Li L, Wozniak L, Rodder S, Heish S, Talisetti A, Wang Q . A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation. Am J Transplant. 2012; 12(5):1218-28. DOI: 10.1111/j.1600-6143.2011.03928.x. View

19.

Bahador A, Hadjati J, Hassannejad N, Ghazanfari H, Maracy M, Jafari S . Frequencies of CD4+ T Regulatory Cells and their CD25(high) and FoxP3(high) Subsets Augment in Peripheral Blood of Patients with Acute and Chronic Brucellosis. Osong Public Health Res Perspect. 2014; 5(3):161-8. PMC: 4147229. DOI: 10.1016/j.phrp.2014.04.008. View

20.

Waldmann H, Adams E, Fairchild P, Cobbold S . Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol Rev. 2006; 212:301-13. DOI: 10.1111/j.0105-2896.2006.00406.x. View