Profiling of Cerebrospinal Fluid Lipids and Their Relationship with Plasma Lipids in Healthy Humans

Overview

Journal Metabolites

Publisher MDPI

Date 2021 Apr 30

PMID 33923144

Citations 13

Authors

Kosuke Saito

Kotaro Hattori

Shinsuke Hidese

Daimei Sasayama

Tomoko Miyakawa

Ryo Matsumura

Megumi Tatsumi

Yuuki Yokota

Miho Ota

Hiroaki Hori

Hiroshi Kunugi

Affiliations

Soon will be listed here.

Abstract

Lipidomics provides an overview of lipid profiles in biological systems. Although blood is commonly used for lipid profiling, cerebrospinal fluid (CSF) is more suitable for exploring lipid homeostasis in brain diseases. However, whether an individual's background affects the CSF lipid profile remains unclear, and the association between CSF and plasma lipid profiles in heathy individuals has not yet been defined. Herein, lipidomics approaches were employed to analyze CSF and plasma samples obtained from 114 healthy Japanese subjects. Results showed that the global lipid profiles differed significantly between CSF and plasma, with only 13 of 114 lipids found to be significantly correlated between the two matrices. Additionally, the CSF total protein content was the primary factor associated with CSF lipids. In the CSF, the levels of major lipids, namely, phosphatidylcholines, sphingomyelins, and cholesterolesters, correlated with CSF total protein levels. These findings indicate that CSF lipidomics can be applied to explore changes in lipid homeostasis in patients with brain diseases.

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