: A Quick Review on Identification, Current Treatments, and Challenges

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Apr 30

PMID 33922907

Citations 35

Authors

Lucia cernakova

Maryam Roudbary

Susana Bras

Silva Tafaj

Celia F Rodrigues

Affiliations

Soon will be listed here.

Abstract

is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of infections highly difficult. This review intends to quickly illustrate the main issues in identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported.

Citing Articles

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Prevalence and Outcomes of Candida auris Infections in a Tertiary Hospital in the United Arab Emirates (UAE).

Subhi A, Alshamsi S, Vitus A, Harazeen A Cureus. 2024; 16(9):e69988.

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Resistance and virulence genes characteristic of a South Asia Clade (I) Candida auris strain isolated from blood in Beijing.

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Candida auris-a systematic review to inform the world health organization fungal priority pathogens list.

Kim PhD H, Nguyen MSc T, Kidd PhD S, Chambers MD J, Alastruey-Izquierdo PhD A, Shin MD J Med Mycol. 2024; 62(6).

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Frota H, Barbosa P, Lorentino C, Affonso L, Ramos L, Oliveira S Biometals. 2024; 37(5):1237-1253.

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References

Barnes R, Gow N, Denning D, May R, Haynes K . Antifungal resistance: more research needed. Lancet. 2014; 384(9952):1427. DOI: 10.1016/S0140-6736(14)61861-4. View

Sharma C, Kumar N, Meis J, Pandey R, Chowdhary A . Draft Genome Sequence of a Fluconazole-Resistant Candida auris Strain from a Candidemia Patient in India. Genome Announc. 2015; 3(4). PMC: 4505117. DOI: 10.1128/genomeA.00722-15. View

Theill L, Dudiuk C, Morales-Lopez S, Berrio I, Rodriguez J, Marin A . Single-tube classical PCR for Candida auris and Candida haemulonii identification. Rev Iberoam Micol. 2018; 35(2):110-112. DOI: 10.1016/j.riam.2018.01.003. View

Khan Z, Ahmad S, Al-Sweih N, Joseph L, Alfouzan W, Asadzadeh M . Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait. PLoS One. 2018; 13(4):e0195743. PMC: 5891028. DOI: 10.1371/journal.pone.0195743. View

Sexton D, Bentz M, Welsh R, Litvintseva A . Evaluation of a new T2 Magnetic Resonance assay for rapid detection of emergent fungal pathogen Candida auris on clinical skin swab samples. Mycoses. 2018; 61(10):786-790. DOI: 10.1111/myc.12817. View

Cortegiani A, Misseri G, Giarratano A, Bassetti M, Eyre D . The global challenge of Candida auris in the intensive care unit. Crit Care. 2019; 23(1):150. PMC: 6495550. DOI: 10.1186/s13054-019-2449-y. View

Rodrigues M, Gomes F, Rodrigues C . spp./Bacteria Mixed Biofilms. J Fungi (Basel). 2019; 6(1). PMC: 7151131. DOI: 10.3390/jof6010005. View

Walraven C, Lee S . Antifungal lock therapy. Antimicrob Agents Chemother. 2012; 57(1):1-8. PMC: 3535896. DOI: 10.1128/AAC.masthead.57-1. View

Villanueva-Lozano H, Trevino-Rangel R, Gonzalez G, Ramirez-Elizondo M, Lara-Medrano R, Aleman-Bocanegra M . Outbreak of Candida auris infection in a COVID-19 hospital in Mexico. Clin Microbiol Infect. 2021; . PMC: 7835657. DOI: 10.1016/j.cmi.2020.12.030. View

10.

Sexton D, Kordalewska M, Bentz M, Welsh R, Perlin D, Litvintseva A . Direct Detection of Emergent Fungal Pathogen Candida auris in Clinical Skin Swabs by SYBR Green-Based Quantitative PCR Assay. J Clin Microbiol. 2018; 56(12). PMC: 6258843. DOI: 10.1128/JCM.01337-18. View

11.

Fujii S, Yabe K, Kariwano-Kimura Y, Furukawa M, Itoh K, Matsuura M . Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis. Congenit Anom (Kyoto). 2018; 59(2):39-42. DOI: 10.1111/cga.12282. View

12.

Srivastava V, Ahmad A . Abrogation of pathogenic attributes in drug resistant Candida auris strains by farnesol. PLoS One. 2020; 15(5):e0233102. PMC: 7213696. DOI: 10.1371/journal.pone.0233102. View

13.

Jaggavarapu S, Burd E, Weiss D . Micafungin and amphotericin B synergy against Candida auris. Lancet Microbe. 2022; 1(8):e314-e315. DOI: 10.1016/S2666-5247(20)30194-4. View

14.

Spivak E, Hanson K . Candida auris: an Emerging Fungal Pathogen. J Clin Microbiol. 2017; 56(2). PMC: 5786713. DOI: 10.1128/JCM.01588-17. View

15.

Singh R, Kaur M, Chakrabarti A, Shankarnarayan S, Rudramurthy S . Biofilm formation by Candida auris isolated from colonising sites and candidemia cases. Mycoses. 2019; 62(8):706-709. DOI: 10.1111/myc.12947. View

16.

Tan J, Liu Z, Sun Y, Yang L, Gao L . Inhibitory Effects of Photodynamic Inactivation on Planktonic Cells and Biofilms of Candida auris. Mycopathologia. 2019; 184(4):525-531. DOI: 10.1007/s11046-019-00352-9. View

17.

Ahmad A, Spencer J, Lockhart S, Singleton S, Petway D, Bagarozzi Jr D . A high-throughput and rapid method for accurate identification of emerging multidrug-resistant Candida auris. Mycoses. 2019; 62(6):513-518. PMC: 10888143. DOI: 10.1111/myc.12907. View

18.

Kordalewska M, Zhao Y, Lockhart S, Chowdhary A, Berrio I, Perlin D . Rapid and Accurate Molecular Identification of the Emerging Multidrug-Resistant Pathogen Candida auris. J Clin Microbiol. 2017; 55(8):2445-2452. PMC: 5527423. DOI: 10.1128/JCM.00630-17. View

19.

Lockhart S . Candida auris and multidrug resistance: Defining the new normal. Fungal Genet Biol. 2019; 131:103243. DOI: 10.1016/j.fgb.2019.103243. View

20.

Arendrup M, Prakash A, Meletiadis J, Sharma C, Chowdhary A . Comparison of EUCAST and CLSI Reference Microdilution MICs of Eight Antifungal Compounds for Candida auris and Associated Tentative Epidemiological Cutoff Values. Antimicrob Agents Chemother. 2017; 61(6). PMC: 5444165. DOI: 10.1128/AAC.00485-17. View