The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Apr 30

PMID 33921963

Citations 1

Authors

Rachel McNamar

Katrina Rothblum

Lawrence I Rothblum

Affiliations

Soon will be listed here.

Abstract

Ribosomal RNA synthesis is the rate-limiting step in ribosome biogenesis. In eukaryotes, RNA polymerase I (Pol I) is responsible for transcribing the ribosomal DNA genes that reside in the nucleolus. Aberrations in Pol I activity have been linked to the development of multiple cancers and other genetic diseases. Therefore, it is key that we understand the mechanisms of Pol I transcription. Recent studies have demonstrated that there are many differences between Pol I transcription in yeast and mammals. Our goal is to highlight the similarities and differences between the polymerase-associated factors (PAFs) in yeast and mammalian cells. We focus on the PAF heterodimer A49/34 in yeast and PAF53/49 in mammals. Recent studies have demonstrated that while the structures between the yeast and mammalian orthologs are very similar, they may function differently during Pol I transcription, and their patterns of regulation are different.

Citing Articles

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.

Daiss J, Pilsl M, Straub K, Bleckmann A, Hocherl M, Heiss F Life Sci Alliance. 2022; 5(11).

PMID: 36271492 PMC: 9438803. DOI: 10.26508/lsa.202201568.

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