Mediterranean Diet and Type 2 Diabetes Mellitus: A Perpetual Inspiration for the Scientific World. A Review

Overview

Journal Nutrients

Date 2021 Apr 30

PMID 33920947

Citations 24

Authors

Tatjana Milenkovic

Nadica Bozhinovska

Djuro Macut

Jelica Bjekic-Macut

Dario Rahelic

Zelija Velija Asimi

Azra Burekovic

Affiliations

Soon will be listed here.

Abstract

For the past 80 years, the effect of the Mediterranean diet on overall health has been a constant topic of interest among medical and scientific researchers. Parallel with the persistent global rise of cases of type 2 diabetes, many studies conducted in the past 20 years have shown the benefits of the Mediterranean lifestyle for people with, or at risk of developing, type 2 diabetes mellitus. However, despite the large body of evidence, concerns exist amongst scientists regarding the reliability of the data related to this topic. This review offers a glimpse of the onset of the Mediterranean diet and follows its significant impact on the prevention and treatment of type 2 diabetes. There is a constant rise in type 2 diabetes cases on the Balkan Peninsula and North Macedonia in particular. Having in mind that North Macedonia, as well as most of the countries on the Balkans have low to middle income, there is a need for a certain affordable dietary pattern to ameliorate the rise in diabetes incidence, as well as improve the glycemic control. We did a review based on the available literature regarding Mediterranean diet and people with or at risk of developing type 2 diabetes mellitus, its effects on glycemic control, lipid profile and metabolic outcome.

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References

Ye J . Mechanisms of insulin resistance in obesity. Front Med. 2013; 7(1):14-24. PMC: 3936017. DOI: 10.1007/s11684-013-0262-6. View

. 9. Pharmacologic Approaches to Glycemic Treatment: . Diabetes Care. 2019; 43(Suppl 1):S98-S110. DOI: 10.2337/dc20-S009. View

Covas M, Nyyssonen K, Poulsen H, Kaikkonen J, Zunft H, Kiesewetter H . The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006; 145(5):333-41. DOI: 10.7326/0003-4819-145-5-200609050-00006. View

Martinez-Lacoba R, Pardo-Garcia I, Amo-Saus E, Escribano-Sotos F . Mediterranean diet and health outcomes: a systematic meta-review. Eur J Public Health. 2018; 28(5):955-961. DOI: 10.1093/eurpub/cky113. View

Esposito K, Chiodini P, Maiorino M, Bellastella G, Panagiotakos D, Giugliano D . Which diet for prevention of type 2 diabetes? A meta-analysis of prospective studies. Endocrine. 2014; 47(1):107-16. DOI: 10.1007/s12020-014-0264-4. View

Smokovski I, Milenkovic T, Trapp C, Mitov A . Diabetes Care in Republic of Macedonia: Challenges and Opportunities. Ann Glob Health. 2016; 81(6):792-802. DOI: 10.1016/j.aogh.2015.12.017. View

Clemente-Postigo M, Queipo-Ortuno M, Murri M, Boto-Ordonez M, Perez-Martinez P, Andres-Lacueva C . Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. J Lipid Res. 2012; 53(5):973-978. PMC: 3329396. DOI: 10.1194/jlr.P020909. View

Kalm L, Semba R . They starved so that others be better fed: remembering Ancel Keys and the Minnesota experiment. J Nutr. 2005; 135(6):1347-52. DOI: 10.1093/jn/135.6.1347. View

Paniagua J, Gallego de la Sacristana A, Sanchez E, Romero I, Vidal-Puig A, Berral F . A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects. J Am Coll Nutr. 2007; 26(5):434-44. DOI: 10.1080/07315724.2007.10719633. View

10.

Schwingshackl L, Chaimani A, Hoffmann G, Schwedhelm C, Boeing H . A network meta-analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus. Eur J Epidemiol. 2018; 33(2):157-170. PMC: 5871653. DOI: 10.1007/s10654-017-0352-x. View

11.

Salas-Salvado J, Fernandez-Ballart J, Ros E, Martinez-Gonzalez M, Fito M, Estruch R . Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial. Arch Intern Med. 2008; 168(22):2449-2458. DOI: 10.1001/archinte.168.22.2449. View

12.

Schwingshackl L, Hoffmann G, Lampousi A, Knuppel S, Iqbal K, Schwedhelm C . Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2017; 32(5):363-375. PMC: 5506108. DOI: 10.1007/s10654-017-0246-y. View

13.

Mirabelli M, Chiefari E, Arcidiacono B, Corigliano D, Brunetti F, Maggisano V . Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases. Nutrients. 2020; 12(4). PMC: 7230471. DOI: 10.3390/nu12041066. View

14.

Seshasai S, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N . Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011; 364(9):829-841. PMC: 4109980. DOI: 10.1056/NEJMoa1008862. View

15.

Violi F, Loffredo L, Pignatelli P, Angelico F, Bartimoccia S, Nocella C . Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects. Nutr Diabetes. 2015; 5:e172. PMC: 4521177. DOI: 10.1038/nutd.2015.23. View

16.

Tong X, Dong J, Wu Z, Li W, Qin L . Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur J Clin Nutr. 2011; 65(9):1027-31. DOI: 10.1038/ejcn.2011.62. View

17.

Martinez-Gonzalez M, de la Fuente-Arrillaga C, Nunez-Cordoba J, Basterra-Gortari F, Beunza J, Vazquez Z . Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study. BMJ. 2008; 336(7657):1348-51. PMC: 2427084. DOI: 10.1136/bmj.39561.501007.BE. View

18.

Li M, Fan Y, Zhang X, Hou W, Tang Z . Fruit and vegetable intake and risk of type 2 diabetes mellitus: meta-analysis of prospective cohort studies. BMJ Open. 2014; 4(11):e005497. PMC: 4225228. DOI: 10.1136/bmjopen-2014-005497. View

19.

Davies M, DAlessio D, Fradkin J, Kernan W, Mathieu C, Mingrone G . Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018; 41(12):2669-2701. PMC: 6245208. DOI: 10.2337/dci18-0033. View

20.

Mazzocchi A, Leone L, Agostoni C, Pali-Scholl I . The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?. Nutrients. 2019; 11(12). PMC: 6949890. DOI: 10.3390/nu11122941. View