Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Apr 30

PMID 33920762

Citations 17

Authors

Nathalia Meireles Da Costa

Fabio A Mendes

Bruno Pontes

Luiz Eurico Nasciutti

Luis Felipe Ribeiro Pinto

Antonio Palumbo Junior

Affiliations

Soon will be listed here.

Abstract

Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Laminin subtypes 111 (LN-111) and 332 (LN-332) are the main isoforms associated with malignant transformation, contributing to proliferation, adhesion, migration, invasion, and metastasis, due to its involvement in the regulation of several pathways associated with HNSCC carcinogenesis, including the activation of the EGFR/MAPK signaling pathway. Therefore, it draws attention to the possibility that laminin may represent a convergence point in HNSCC natural history, and an attractive potential therapeutic target for these tumors.

Citing Articles

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References

Fulop T, Larbi A . Putative role of 67 kDa elastin-laminin receptor in tumor invasion. Semin Cancer Biol. 2002; 12(3):219-29. DOI: 10.1016/S1044-579X(02)00025-1. View

Engel J, Odermatt E, Engel A, Madri J, Furthmayr H, Rohde H . Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix. J Mol Biol. 1981; 150(1):97-120. DOI: 10.1016/0022-2836(81)90326-0. View

Nordemar S, Kronenwett U, Auer G, Hogmo A, Lindholm J, Edstrom S . Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx. Anticancer Res. 2001; 21(1B):509-12. View

Siqueira A, Gama-de-Souza L, Arnaud M, Pinheiro J, Jaeger R . Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin. Tumour Biol. 2010; 31(1):46-58. DOI: 10.1007/s13277-009-0008-x. View

Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino H . Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma. Br J Cancer. 2013; 109(10):2636-45. PMC: 3833206. DOI: 10.1038/bjc.2013.607. View

Farwell D, McDougall J, Coltrera M . Expression of Epstein-Barr virus latent membrane proteins leads to changes in keratinocyte cell adhesion. Ann Otol Rhinol Laryngol. 1999; 108(9):851-9. DOI: 10.1177/000348949910800906. View

Junior H, Rocha V, Leite C, de Aguiar M, Souza P, Horta M . Laminin-5 gamma 2 chain expression is associated with intensity of tumor budding and density of stromal myofibroblasts in oral squamous cell carcinoma. J Oral Pathol Med. 2013; 43(3):199-204. DOI: 10.1111/jop.12121. View

Snijders A, Schmidt B, Fridlyand J, Dekker N, Pinkel D, Jordan R . Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene. 2005; 24(26):4232-42. DOI: 10.1038/sj.onc.1208601. View

Oku N, Sasabe E, Ueta E, Yamamoto T, Osaki T . Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1. Cancer Res. 2006; 66(10):5251-7. DOI: 10.1158/0008-5472.CAN-05-4478. View

10.

Kunitomi H, Kobayashi Y, Wu R, Takeda T, Tominaga E, Banno K . LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer. J Gynecol Oncol. 2020; 31(2):e11. PMC: 7044014. DOI: 10.3802/jgo.2020.31.e11. View

11.

Ricci E, Cavalot A, Sanvito F, Bussi M, Albera R, Staffieri A . Differential expression and topography of adhesion molecules in laryngeal and oropharyngeal carcinomas. Acta Otolaryngol. 2002; 122(2):234-40. DOI: 10.1080/00016480252814298. View

12.

Tran M, Rousselle P, Nokelainen P, Tallapragada S, Nguyen N, Fincher E . Targeting a tumor-specific laminin domain critical for human carcinogenesis. Cancer Res. 2008; 68(8):2885-94. DOI: 10.1158/0008-5472.CAN-07-6160. View

13.

Nakayama M, Sato Y, Okamoto M, Hirohashi S . Increased expression of laminin-5 and its prognostic significance in hypopharyngeal cancer. Laryngoscope. 2004; 114(7):1259-63. DOI: 10.1097/00005537-200407000-00022. View

14.

De Schryver A, Friberg Jr S, Klein G, Henle W, Henle G, Clifford P . Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space. Clin Exp Immunol. 1969; 5(5):443-59. PMC: 1579142. View

15.

. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-82. PMC: 4311405. DOI: 10.1038/nature14129. View

16.

Holler E . Laminin isoform expression in breast tumors. Breast Cancer Res. 2005; 7(4):166-7. PMC: 1175076. DOI: 10.1186/bcr1270. View

17.

Pezzuto F, Buonaguro L, Caponigro F, Ionna F, Starita N, Annunziata C . Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies. Oncology. 2015; 89(3):125-36. DOI: 10.1159/000381717. View

18.

Hao J, Jackson L, Calaluce R, McDaniel K, Dalkin B, Nagle R . Investigation into the mechanism of the loss of laminin 5 (alpha3beta3gamma2) expression in prostate cancer. Am J Pathol. 2001; 158(3):1129-35. PMC: 1850351. DOI: 10.1016/s0002-9440(10)64060-6. View

19.

Wang S, Liou G, Liu S, Chang J, Hsiao J, Yen Y . Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells. Int J Cancer. 2018; 144(11):2795-2810. DOI: 10.1002/ijc.32027. View

20.

Henke E, Nandigama R, Ergun S . Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy. Front Mol Biosci. 2020; 6:160. PMC: 7025524. DOI: 10.3389/fmolb.2019.00160. View