Association of and Polymorphisms with Litter Size Traits in Pigs

Overview

Journal Animals (Basel)

Date 2021 Apr 30

PMID 33920608

Citations 2

Authors

Worrarak Norseeda

Guisheng Liu

Tawatchai Teltathum

Pantaporn Supakankul

Korawan Sringarm

Watcharapong Naraballobh

Trisadee Khamlor

Siriwadee Chomdej

Korakot Nganvongpanit

Patcharin Krutmuang

Supamit Mekchay

Affiliations

Soon will be listed here.

Abstract

The interleukin-4 (IL-4) and interleukin-4 receptor (IL-4R) are cytokines that are involved in the immune and reproductive systems. This study aimed to verify the polymorphisms in the porcine and genes and to assess their effects on litter size traits in commercial pigs. Single nucleotide polymorphisms (SNPs) in the porcine and genes were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A non-coding SNP of g.134993898T > C and a non-synonymous SNP of c.1577A > T (amino acid change at position 526, Q526L) were found to be segregating in Landrace sows. The g.134993898T > C polymorphism was significantly associated with the number of piglets weaned alive (NWA) trait. The c.1577A > T polymorphism was significantly associated with the number born alive (NBA) and NWA traits. Moreover, the accumulation of favorable alleles of these two SNP markers revealed significant associations with the NBA, NWA, and mean weight of piglets at weaning (MWW) traits. These findings indicate that the porcine and genes may contribute to the reproductive traits of pigs and could be used as candidate genes to improve litter size traits in the pig breeding industry.

Citing Articles

Effect of SNPs on Litter Size in Swine.

Guo Z, Lv L, Liu D, Ma H, Radovic C Curr Issues Mol Biol. 2024; 46(7):6328-6345.

PMID: 39057020 PMC: 11276056. DOI: 10.3390/cimb46070378.

Heterozygosity and homozygosity regions affect reproductive success and the loss of reproduction: A case study with litter traits in pigs.

Chen Z, Zhang Z, Wang Z, Zhang Z, Wang Q, Pan Y Comput Struct Biotechnol J. 2022; 20:4060-4071.

PMID: 35983229 PMC: 9364102. DOI: 10.1016/j.csbj.2022.07.039.

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