Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2021 Apr 30

PMID 33920204

Citations 50

Authors

Eitan Mijiritsky

Haya Drora Assaf

Oren Peleg

Maayan Shacham

Loredana Cerroni

Luca Mangani

Affiliations

Soon will be listed here.

Abstract

Growth factors (GFs) play a vital role in cell proliferation, migration, differentiation and angiogenesis. Autologous platelet concentrates (APCs) which contain high levels of GFs make them especially suitable for periodontal regeneration and facial rejuvenation. The main generations of APCs presented are platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) techniques. The purpose of this review is to provide the clinician with an overview of APCs' evolution over the past decade in order to give reliable and useful information to be used in clinical work. This review summarizes the most interesting and novel articles published between 1997 and 2020. Electronic and manual searches were conducted in the following databases: Pubmed, Scopus, Cochrane Library and Embase. The following keywords were used: growth factors, VEGF, TGF-b1, PRP, PRF, CGF and periodontal regeneration and/or facial rejuvenation. A total of 73 articles were finally included. The review then addresses the uses of the three different techniques in the two disciplines, as well as the advantages and limitations of each technique. Overall, PRP is mainly used in cases of hard and soft tissue procedures, while PRF is used in gingival recession and the treatment of furcation and intrabony defects; CGF is mainly used in bone regeneration.

Citing Articles

Bioactivity of dressings based on platelet-rich plasma and Platelet-rich fibrin for tissue regeneration in animal model.

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The effect of autologous platelet concentrates as solely grafting material or with bone graft materials in maxillary sinus augmentation: a meta-analysis of randomized controlled trials.

Xie S, Zhang Y, Wen G, Qu H, Dong W Clin Oral Investig. 2025; 29(2):120.

PMID: 39920362 DOI: 10.1007/s00784-025-06198-4.

Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy.

Liu M, Zhang L, Zhang Q, Zeng N, Li S, Guo S Braz J Otorhinolaryngol. 2025; 91(3):101561.

PMID: 39914043 PMC: 11848466. DOI: 10.1016/j.bjorl.2025.101561.

The Effect of Autologous Platelet Rich Plasma on Endometrial Receptivity: A Narrative Review.

Stefanovic M, Vukomanovic P, Kutlesic R, Trenkic M, Dimitrov V, Stefanovic A Medicina (Kaunas). 2025; 61(1).

PMID: 39859116 PMC: 11767130. DOI: 10.3390/medicina61010134.

Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis.

Lipovec T, Kapadia N, Antonoglou G, Lu E, El-Sayed K, Nibali L Clin Oral Investig. 2025; 29(1):74.

PMID: 39841297 PMC: 11754314. DOI: 10.1007/s00784-024-06128-w.

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