Antihyperglycemic and Antilipidemic Properties of a Tea Infusion of the Leaves from Miller on Streptozocin-Induced Type 2 Diabetic Mice

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Apr 30

PMID 33919145

Citations 9

Authors

Jesus Martinez-Solis

Fernando Calzada

Elizabeth Barbosa

Miguel Valdes

Affiliations

Soon will be listed here.

Abstract

The antihyperglycemic and antilipidemic effects of the tea infusion extracts of leaves from Miller (IELAc-0.5, IELAc-1.5, and IELAc-3.0) were evaluated on normoglycemic (NG) and streptozocin-induced diabetic (STID) mice. In the acute test, IELAc-1.5 at 300 mg/kg bodyweight (bw) exhibited antihyperglycemic activity on STID mice since the first hour of treatment. Then, its antidiabetic potential was analyzed in a subchronic evaluation. IELAc-1.5 was able to reduce the blood glucose level, glycated hemoglobin (HbA1c), cholesterol (CHO), and triglycerides (TG); high-density lipoprotein (HDL) showed an increase at the end of treatment. IELAc-1.5 did not modify the urine profile at the end of the evaluation, and neither toxicity nor macroscopic organ damage were observed in acute and subchronic assays. In addition, a major flavonol glycoside present in the tea infusion extracts was identified using high-performance liquid chromatography with diode array detection (HPLC-DAD). The analysis of the tea infusion extracts by HPLC revealed that rutin was the major component. This study supports the use of tea infusions from for the treatment of diabetes and suggests that rutin could be responsible, at least in part, for their antidiabetic properties.

Citing Articles

Miller and Its Flavonoids, an Important Source of Products for the Treatment of Diabetes Mellitus: In Vivo and In Silico Evaluations.

Calzada F, Valdes M, Martinez-Solis J, Velazquez C, Barbosa E Pharmaceuticals (Basel). 2023; 16(5).

PMID: 37242507 PMC: 10222912. DOI: 10.3390/ph16050724.

Modulatory Effect of Medicinal Plants and Their Active Constituents on ATP-Sensitive Potassium Channels (K) in Diabetes.

Al Kury L Pharmaceuticals (Basel). 2023; 16(4).

PMID: 37111281 PMC: 10142548. DOI: 10.3390/ph16040523.

Antihyperglycemic Effects of Miller and the Flavonoid Rutin in Combination with Oral Antidiabetic Drugs on Streptozocin-Induced Diabetic Mice.

Valdes M, Calzada F, Martinez-Solis J, Martinez-Rodriguez J Pharmaceuticals (Basel). 2023; 16(1).

PMID: 36678609 PMC: 9865614. DOI: 10.3390/ph16010112.

Experimental Approaches to Diabetes Mellitus.

Yayla M, Binnetoglu D Eurasian J Med. 2023; 54(Suppl1):145-153.

PMID: 36655459 PMC: 11163337. DOI: 10.5152/eurasianjmed.2022.22304.

Antidiabetic and Toxicological Effects of the Tea Infusion of Summer Collection from Miller Leaves.

Martinez-Solis J, Calzada F, Barbosa E, Gutierrez-Meza J Plants (Basel). 2022; 11(23).

PMID: 36501263 PMC: 9740447. DOI: 10.3390/plants11233224.

References

Kaleem M, Asif M, Ahmed Q, Bano B . Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2006; 47(8):670-5. View

Galarce-Bustos O, Fernandez-Ponce M, Montes A, Pereyra C, Casas L, Mantell C . Usage of supercritical fluid techniques to obtain bioactive alkaloid-rich extracts from cherimoya peel and leaves: extract profiles and their correlation with antioxidant properties and acetylcholinesterase and α-glucosidase inhibitory activities. Food Funct. 2020; 11(5):4224-4235. DOI: 10.1039/d0fo00342e. View

Vasarri M, Barletta E, Vinci S, Ramazzotti M, Francesconi A, Manetti F . Miller Fruit as a Promising Candidate against Diabetic Complications: An In Vitro Study and Preliminary Clinical Results. Foods. 2020; 9(10). PMC: 7598707. DOI: 10.3390/foods9101350. View

Choudhury H, Pandey M, Hua C, Mun C, Jing J, Kong L . An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 2018; 8(3):361-376. PMC: 6035310. DOI: 10.1016/j.jtcme.2017.08.012. View

Fischer S, Hanefeld M, Spengler M, Boehme K, Temelkova-Kurktschiev T . European study on dose-response relationship of acarbose as a first-line drug in non-insulin-dependent diabetes mellitus: efficacy and safety of low and high doses. Acta Diabetol. 1998; 35(1):34-40. DOI: 10.1007/s005920050098. View

Mannino G, Gentile C, Porcu A, Agliassa C, Caradonna F, Bertea C . Chemical Profile and Biological Activity of Cherimoya ( Mill.) and Atemoya () Leaves. Molecules. 2020; 25(11). PMC: 7321297. DOI: 10.3390/molecules25112612. View

Diaz-de-Cerio E, Aguilera-Saez L, Gomez-Caravaca A, Verardo V, Fernandez-Gutierrez A, Fernandez I . Characterization of bioactive compounds of Annona cherimola L. leaves using a combined approach based on HPLC-ESI-TOF-MS and NMR. Anal Bioanal Chem. 2018; 410(15):3607-3619. DOI: 10.1007/s00216-018-1051-5. View

Shikov A, Pozharitskaya O, Makarov V . Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen: An overview of pharmacological studies. Phytomedicine. 2016; 23(12):1409-1421. DOI: 10.1016/j.phymed.2016.07.011. View

Guthrie R, Guthrie D . Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004; 27(2):113-25. DOI: 10.1097/00002727-200404000-00003. View

10.

Corcoran M, McKay D, Blumberg J . Flavonoid basics: chemistry, sources, mechanisms of action, and safety. J Nutr Gerontol Geriatr. 2012; 31(3):176-89. DOI: 10.1080/21551197.2012.698219. View

11.

Gothai S, Ganesan P, Park S, Fakurazi S, Choi D, Arulselvan P . Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target. Nutrients. 2016; 8(8). PMC: 4997374. DOI: 10.3390/nu8080461. View

12.

Jung U, Lee M, Park Y, Kang M, Choi M . Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol. 2006; 38(7):1134-45. DOI: 10.1016/j.biocel.2005.12.002. View

13.

Garcia-Chapa E, Leal-Ugarte E, Peralta-Leal V, Duran-Gonzalez J, Meza-Espinoza J . Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos. Biomed Res Int. 2017; 2017():3937893. PMC: 5451767. DOI: 10.1155/2017/3937893. View

14.

Ammoury C, Younes M, El Khoury M, Hodroj M, Haykal T, Nasr P . The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines. BMC Complement Altern Med. 2019; 19(1):365. PMC: 6909458. DOI: 10.1186/s12906-019-2768-1. View

15.

Tadera K, Minami Y, Takamatsu K, Matsuoka T . Inhibition of alpha-glucosidase and alpha-amylase by flavonoids. J Nutr Sci Vitaminol (Tokyo). 2006; 52(2):149-53. DOI: 10.3177/jnsv.52.149. View

16.

Leite D, de F A Nonato C, Camilo C, de Carvalho N, da Nobrega M, Pereira R . Annona Genus: Traditional Uses, Phytochemistry and Biological Activities. Curr Pharm Des. 2020; 26(33):4056-4091. DOI: 10.2174/1381612826666200325094422. View

17.

Kovatchev B . Metrics for glycaemic control - from HbA to continuous glucose monitoring. Nat Rev Endocrinol. 2017; 13(7):425-436. DOI: 10.1038/nrendo.2017.3. View

18.

Maritim A, Sanders R, Watkins 3rd J . Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003; 17(1):24-38. DOI: 10.1002/jbt.10058. View

19.

Yaseen G, Ahmad M, Zafar M, Sultana S, Kayani S, Cetto A . Traditional management of diabetes in Pakistan: Ethnobotanical investigation from Traditional Health Practitioners. J Ethnopharmacol. 2015; 174:91-117. DOI: 10.1016/j.jep.2015.07.041. View

20.

Larranaga N, Albertazzi F, Fontecha G, Palmieri M, Rainer H, van Zonneveld M . A Mesoamerican origin of cherimoya (Annona cherimola Mill.): Implications for the conservation of plant genetic resources. Mol Ecol. 2017; 26(16):4116-4130. DOI: 10.1111/mec.14157. View