Nanomaterials in Wound Healing and Infection Control

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Apr 30

PMID 33919072

Citations 30

Authors

Ali Pormohammad

Nadia K Monych

Sougata Ghosh

Diana L Turner

Raymond J Turner

Affiliations

Soon will be listed here.

Abstract

Wounds continue to be a serious medical concern due to their increasing incidence from injuries, surgery, burns and chronic diseases such as diabetes. Delays in the healing process are influenced by infectious microbes, especially when they are in the biofilm form, which leads to a persistent infection. Biofilms are well known for their increased antibiotic resistance. Therefore, the development of novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm and wound healing properties are required. Nanomaterials (NM) have unique properties due to their size and very large surface area that leads to a wide range of applications. Several NMs have antimicrobial activity combined with wound regeneration features thus give them promising applicability to a variety of wound types. The idea of NM-based antibiotics has been around for a decade at least and there are many recent reviews of the use of nanomaterials as antimicrobials. However, far less attention has been given to exploring if these NMs actually improve wound healing outcomes. In this review, we present an overview of different types of nanomaterials explored specifically for wound healing properties combined with infection control.

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References

Pivodova V, Frankova J, Galandakova A, Ulrichova J . AuNPs' Cytotoxicity and Their Effect on Wound Healing. Nanobiomedicine (Rij). 2018; 2:7. PMC: 5997374. DOI: 10.5772/61132. View

Raghunath A, Perumal E . Metal oxide nanoparticles as antimicrobial agents: a promise for the future. Int J Antimicrob Agents. 2017; 49(2):137-152. DOI: 10.1016/j.ijantimicag.2016.11.011. View

Turner R . Metal-based antimicrobial strategies. Microb Biotechnol. 2017; 10(5):1062-1065. PMC: 5609261. DOI: 10.1111/1751-7915.12785. View

Li Q, Lu F, Zhou G, Yu K, Lu B, Xiao Y . Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing. Biomacromolecules. 2017; 18(11):3766-3775. DOI: 10.1021/acs.biomac.7b01180. View

Lee J, Kim J, Go J, Lee J, Han D, Hwang D . Transdermal treatment of the surgical and burned wound skin via phytochemical-capped gold nanoparticles. Colloids Surf B Biointerfaces. 2015; 135:166-174. DOI: 10.1016/j.colsurfb.2015.07.058. View

Gao W, Chen Y, Zhang Y, Zhang Q, Zhang L . Nanoparticle-based local antimicrobial drug delivery. Adv Drug Deliv Rev. 2017; 127:46-57. PMC: 5860926. DOI: 10.1016/j.addr.2017.09.015. View

Jiang Y, Zhang L, Wen D, Ding Y . Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against E. coli. Mater Sci Eng C Mater Biol Appl. 2016; 69:1361-6. DOI: 10.1016/j.msec.2016.08.044. View

Lee S, Park S, Kim Y, Im H, Choi J . Effect of sulfidation and dissolved organic matters on toxicity of silver nanoparticles in sediment dwelling organism, Chironomus riparius. Sci Total Environ. 2016; 553:565-573. DOI: 10.1016/j.scitotenv.2016.02.064. View

Barillo D, Marx D . Silver in medicine: a brief history BC 335 to present. Burns. 2014; 40 Suppl 1:S3-8. DOI: 10.1016/j.burns.2014.09.009. View

10.

Khan S, Musarrat J, Al-Khedhairy A . Countering drug resistance, infectious diseases, and sepsis using metal and metal oxides nanoparticles: Current status. Colloids Surf B Biointerfaces. 2016; 146:70-83. DOI: 10.1016/j.colsurfb.2016.05.046. View

11.

Mofazzal Jahromi M, Zangabad P, Moosavi Basri S, Sahandi Zangabad K, Ghamarypour A, Aref A . Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing. Adv Drug Deliv Rev. 2017; 123:33-64. PMC: 5742034. DOI: 10.1016/j.addr.2017.08.001. View

12.

Imlay J . Pathways of oxidative damage. Annu Rev Microbiol. 2003; 57:395-418. DOI: 10.1146/annurev.micro.57.030502.090938. View

13.

Kalantari K, Mostafavi E, Afifi A, Izadiyan Z, Jahangirian H, Rafiee-Moghaddam R . Wound dressings functionalized with silver nanoparticles: promises and pitfalls. Nanoscale. 2020; 12(4):2268-2291. DOI: 10.1039/c9nr08234d. View

14.

Dhilip Kumar S, Rajendran N, Houreld N, Abrahamse H . Recent advances on silver nanoparticle and biopolymer-based biomaterials for wound healing applications. Int J Biol Macromol. 2018; 115:165-175. DOI: 10.1016/j.ijbiomac.2018.04.003. View

15.

Naraginti S, Kumari P, Das R, Sivakumar A, Patil S, Vilas Andhalkar V . Amelioration of excision wounds by topical application of green synthesized, formulated silver and gold nanoparticles in albino Wistar rats. Mater Sci Eng C Mater Biol Appl. 2016; 62:293-300. DOI: 10.1016/j.msec.2016.01.069. View

16.

Ternullo S, Schulte Werning L, Mari Holsaeter A, Skalko-Basnet N . Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing. Pharmaceutics. 2019; 12(1). PMC: 7022996. DOI: 10.3390/pharmaceutics12010008. View

17.

Balaure P, Grumezescu A . Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part I: Molecular Basis of Biofilm Recalcitrance. Passive Anti-Biofouling Nanocoatings. Nanomaterials (Basel). 2020; 10(6). PMC: 7353097. DOI: 10.3390/nano10061230. View

18.

Mengoni T, Adrian M, Pereira S, Santos-Carballal B, Kaiser M, Goycoolea F . A Chitosan-Based Liposome Formulation Enhances the In Vitro Wound Healing Efficacy of Substance P Neuropeptide. Pharmaceutics. 2017; 9(4). PMC: 5750662. DOI: 10.3390/pharmaceutics9040056. View

19.

Khorasani M, Joorabloo A, Moghaddam A, Shamsi H, MansooriMoghadam Z . Incorporation of ZnO nanoparticles into heparinised polyvinyl alcohol/chitosan hydrogels for wound dressing application. Int J Biol Macromol. 2018; 114:1203-1215. DOI: 10.1016/j.ijbiomac.2018.04.010. View

20.

Kwiatkowska A, Granicka L, Grzeczkowicz A, Stachowiak R, Bacal P, Sobczak K . Gold Nanoparticle-Modified Poly(vinyl chloride) Surface with Improved Antimicrobial Properties for Medical Devices. J Biomed Nanotechnol. 2018; 14(5):922-932. DOI: 10.1166/jbn.2018.2539. View