Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP Rs1800907: A Retrospective Analysis from Milan Metropolitan Area

Overview

Journal Vaccines (Basel)

Date 2021 Apr 30

PMID 33915945

Citations 1

Authors

Elena M Varoni

Giovanni Lodi

Massimo Del Fabbro

Andrea Sardella

Antonio Carrassi

Marcello Iriti

Pasquale Tripputi

Affiliations

Soon will be listed here.

Abstract

This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype ( < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis ( < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCRβ-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity.

Citing Articles

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PMID: 39407294 PMC: 11477017. DOI: 10.1186/s40101-024-00372-5.

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