The Positive Effect of Eugenol on Acute Pancreatic Tissue Injury: a Rat Experimental Model

Overview

Journal Pan Afr Med J

Date 2021 Apr 29

PMID 33912302

Citations 1

Authors

Alexandra Tsaroucha

Vasileios Kaldis

Michail Vailas

Dimitrios Schizas

Maria Lambropoulou

Apostolos Papalois

Christina Tsigalou

Apostolos Gaitanidis

Michael Pitiakoudis

Constantinos Simopoulos

Affiliations

Soon will be listed here.

Abstract

Introduction: we present a rat experimental model used to evaluate the possible reduction in the extent of pancreatic tissue injury in acute pancreatitis cases, after administration of eugenol.

Methods: one hundred and twenty Wistar rats were used, which were randomly assigned in 3 groups: sham (n=20), control (n=50) and eugenol (n=50). Acute pancreatitis was induced by biliopancreatic ligation in the control and eugenol groups, but not in the Sham group. In the eugenol group, eugenol was administered per-os. Five histopathological parameters, such as edema, inflammatory infiltration, duct dilatation, hemorrhage and acinar necrosis were evaluated.

Results: at 72 h from acute pancreatitis induction, the total histological score was diminished in the eugenol group (p<0.0005) and duct dilatation and inflammatory infiltration were reduced compared to the control group (p<0.05). In addition, at 72 h, eugenol reduced pancreatic myeloperoxidase activity (p<0.0005).

Conclusion: eugenol, a highly free radical scavenger agent, may have a preventive role in acute pancreatic injury, as it was evident in our rat experimental model.

Citing Articles

Eugenol Reduced ΜPO, CD45 and HMGB1 Expression and Attenuated the Expression of Leukocyte Infiltration Markers in the Intestinal Tissue in Biliopancreatic Duct Ligation-Induced Pancreatitis in Rats.

Oikonomou P, Nikolaou C, Papachristou F, Sovatzidis A, Lambropoulou M, Giouleka C Medicina (Kaunas). 2024; 60(1).

PMID: 38256335 PMC: 10820626. DOI: 10.3390/medicina60010074.

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