Eccrine Porocarcinoma: A Multicenter Retrospective Study with Review of the Literatures Reported in Korea

Overview

Journal Ann Dermatol

Specialty Dermatology

Date 2021 Apr 29

PMID 33911741

Citations 8

Authors

Hee Joo Kim

Anna Kim

Kyung-Chul Moon

Soo Hong Seo

Il-Hwan Kim

Aeree Kim

Yoo Sang Baek

Affiliations

Soon will be listed here.

Abstract

Background: Eccrine porocarcinoma (EPC) is a rare malignant cutaneous adnexal tumor. Other than several scattered case reports, no comprehensive review on EPC has been conducted in Korea.

Objective: To clinicopathologically review all EPC cases from our institutions as well as those reported in Korea.

Methods: Medical records and histopathological slides of EPC cases in the skin biopsy registries of our institutions were retrospectively reviewed. Additionally, EPC cases reported in Korea before June 2019 were retrieved by searching the PubMed, KoMCI, KoreaMed, and KMbase databases.

Results: Nine EPC cases from our institutions were included in the study. In addition, 27 reports of 28 patients with EPC were reported in Korea. A total of 37 patients with EPC were identified, consisting of 19 males (male:female ratio, 1.06:1; mean age at diagnosis, 65.6 years). The most common site of primary tumor was the head and neck (29.7%). Wide excision was the most common (78.4%) treatment method. Initial metastasis work-up imaging studies were performed in 18 patients (48.6%), and metastasis was confirmed in eight patients (21.6%).

Conclusion: EPC is a rare cutaneous carcinoma in Korea. EPC usually affects elderly patients, with no sexual predilection. Due to possible metastasis, careful diagnosis and appropriate metastasis work-ups are warranted in EPC.

Citing Articles

Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review.

Bienstman T, Guvenc C, Garmyn M Int J Mol Sci. 2024; 25(11).

PMID: 38891945 PMC: 11172007. DOI: 10.3390/ijms25115760.

An unusual case of eccrine porocarcinoma on the axilla with nodal involvement: A case report.

Maharjan S, Shrestha O, Baral R, Bhattarai A SAGE Open Med Case Rep. 2024; 12:2050313X241256868.

PMID: 38812832 PMC: 11135088. DOI: 10.1177/2050313X241256868.

Comments on "Eccrine Porocarcinoma: A Multicenter Retrospective Study with Review of the Literatures Reported in Korea".

Kim Y, Yang H, Won C Ann Dermatol. 2023; 35(Suppl 1):S1-S3.

PMID: 37853909 PMC: 10608384. DOI: 10.5021/ad.20.178.

Eccrine Porocarcinoma: Clinical and Histopathological Study of 14 Patients with Special Emphasis on Sentinel Lymph Node Biopsy.

Merilainen A, Von Willenbrand-Backmann M, Sihto H, Koljonen V Acta Derm Venereol. 2023; 103:adv11649.

PMID: 37448211 PMC: 10391535. DOI: 10.2340/actadv.v103.11649.

Eccrine Porocarcinoma: A Review of the Literature.

Tsiogka A, Koumaki D, Kyriazopoulou M, Liopyris K, Stratigos A, Gregoriou S Diagnostics (Basel). 2023; 13(8).

PMID: 37189532 PMC: 10137440. DOI: 10.3390/diagnostics13081431.

References

Xu Y, Aylward J, Longley B, Hinshaw M, Snow S . Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. Dermatol Surg. 2015; 41(6):685-92. DOI: 10.1097/DSS.0000000000000382. View

Lozano Orella J, Valcayo Penalba A, San Juan C, Vives Nadal R, Castro Morrondo J, Tunon Alvarez T . Eccrine porocarcinoma. Report of nine cases. Dermatol Surg. 1997; 23(10):925-8. View

Mahalingam M, Richards J, Selim M, Muzikansky A, Hoang M . An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma. Hum Pathol. 2012; 43(8):1265-72. DOI: 10.1016/j.humpath.2011.10.005. View

Cho S, Roh M, Yun M, Yun S, Lee M, Chung K . (18)F-fluorodeoxyglucose positron emission tomography detection of eccrine porocarcinoma. Br J Dermatol. 2005; 152(2):372-3. DOI: 10.1111/j.1365-2133.2005.06314.x. View

Hoshina D, Akiyama M, Hata H, Aoyagi S, Sato-Matsumura K, Shimizu H . Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. Clin Exp Dermatol. 2006; 32(1):54-6. DOI: 10.1111/j.1365-2230.2006.02260.x. View

Lee H, Jeong S, Seo E, Ha S, Kim J . Melanocyte colonization associated with malignant transformation of eccrine poroma. Br J Dermatol. 1999; 141(3):582-3. DOI: 10.1046/j.1365-2133.1999.03070.x. View

Miura K, Namiki T, Otsuki Y, Yokozeki H . Porocarcinoma with hidroacanthoma simplex-like features in association with seborrheic keratosis. Eur J Dermatol. 2017; 27(4):405-406. DOI: 10.1684/ejd.2017.3013. View

Seo B, Choi H, Jung S . Eccrine porocarcinoma on the cheek. Arch Craniofac Surg. 2019; 20(1):48-50. PMC: 6411527. DOI: 10.7181/acfs.2018.02180. View

Choi S, Kim Y, Kim H, Kim H, Nam S, Choi Y . A rare case of abdominal porocarcinoma. Arch Plast Surg. 2014; 41(1):91-3. PMC: 3915165. DOI: 10.5999/aps.2014.41.1.91. View

10.

Choi C, Cho H, Lew B, Sim W . Eccrine porocarcinoma presenting with unusual clinical manifestations: a case report and review of the literature. Ann Dermatol. 2011; 23 Suppl 1:S79-83. PMC: 3199430. DOI: 10.5021/ad.2011.23.S1.S79. View

11.

Liu H, Chang Y, Chen C . Differentiation of hidroacanthoma simplex from clonal seborrheic keratosis--an immunohistochemical study. Am J Dermatopathol. 2004; 26(3):188-93. DOI: 10.1097/00000372-200406000-00003. View

12.

Park J, Kwon H, Cho M, Park Y, Lee S, Lee J . A Case of Malignant Eccrine Poroma Developing on the Suprapubic Area. Ann Dermatol. 2016; 20(1):37-40. PMC: 4904047. DOI: 10.5021/ad.2008.20.1.37. View

13.

Kim W, Kim J, Park C, Kim Y . Successful reconstruction after resection of malignant eccrine poroma using retroauricular artery perforator-based island flap. J Craniofac Surg. 2012; 23(6):e579-82. DOI: 10.1097/SCS.0b013e31826befbb. View

14.

Salih A, Kakamad F, Baba H, Salih R, Hawbash M, Mohammed S . Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg (Lond). 2017; 20:74-79. PMC: 5499034. DOI: 10.1016/j.amsu.2017.06.027. View

15.

Jeon J, Kim J, Baek Y, Kim A, Seo S, Oh C . Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. Am J Dermatopathol. 2014; 36(5):430-2. DOI: 10.1097/DAD.0000000000000012. View

16.

Lee J, Oh C, Jang H, Kim M, Jang B, Kwon K . A case of porocarcinoma from pre-existing hidroacanthoma simplex: need of early excision for hidroacanthoma simplex?. Dermatol Surg. 2003; 29(7):772-4. DOI: 10.1046/j.1524-4725.2003.29195.x. View

17.

Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A . Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature. Dermatol Surg. 2018; 44(10):1247-1261. DOI: 10.1097/DSS.0000000000001566. View

18.

Robson A, Greene J, Ansari N, Kim B, Seed P, McKee P . Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001; 25(6):710-20. DOI: 10.1097/00000478-200106000-00002. View

19.

Madan V, Cox N, Gangopadhayay M . Porocarcinoma arising in a broad clonal seborrhoeic keratosis. Clin Exp Dermatol. 2008; 33(3):350-1. DOI: 10.1111/j.1365-2230.2007.02659.x. View

20.

Kim J, Oh D, Kang M, Lee D, Hwang S, Park S . A case of metastatic eccrine porocarcinoma. Acta Derm Venereol. 2007; 87(6):550-2. DOI: 10.2340/00015555-0310. View