Synthesis of C-enriched Amino Acids with C-depleted Insoluble Organic Matter in a Formose-type Reaction in the Early Solar System

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2021 Apr 29

PMID 33910902

Citations 11

Authors

Yoshihiro Furukawa

Yoshinari Iwasa

Yoshito Chikaraishi

Affiliations

Soon will be listed here.

Abstract

Solvent-soluble organic matter (SOM) in meteorites, which includes life's building molecules, is suspected to originate from the cold region of the early solar system, on the basis of C enrichment in the molecules. Here, we demonstrate that the isotopic characteristics are reproducible in amino acid synthesis associated with a formose-type reaction in a heated aqueous solution. Both thermochemically driven formose-type reaction and photochemically driven formose-type reaction likely occurred in asteroids and ice-dust grains in the early solar system. Thus, the present results suggest that the formation of C-enriched SOM was not specific to the cold outer protosolar disk or the molecular cloud but occurred more widely in the early solar system.

Citing Articles

Stable carbon isotope evolution of formaldehyde on early Mars.

Koyama S, Yoshida T, Furukawa Y, Terada N, Ueno Y, Nakamura Y Sci Rep. 2024; 14(1):21214.

PMID: 39289470 PMC: 11408639. DOI: 10.1038/s41598-024-71301-w.

Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu.

Takano Y, Naraoka H, Dworkin J, Koga T, Sasaki K, Sato H Nat Commun. 2024; 15(1):5708.

PMID: 38987536 PMC: 11237059. DOI: 10.1038/s41467-024-49237-6.

Atmospheric formaldehyde production on early Mars leading to a potential formation of bio-important molecules.

Koyama S, Kamada A, Furukawa Y, Terada N, Nakamura Y, Yoshida T Sci Rep. 2024; 14(1):2397.

PMID: 38336798 PMC: 10858170. DOI: 10.1038/s41598-024-52718-9.

Gamma-Ray-Induced Amino Acid Formation during Aqueous Alteration in Small Bodies: The Effects of Compositions of Starting Solutions.

Ishikawa A, Kebukawa Y, Kobayashi K, Yoda I Life (Basel). 2024; 14(1).

PMID: 38255718 PMC: 10817335. DOI: 10.3390/life14010103.

Aqueous breakdown of aspartate and glutamate to n-ω-amino acids on the parent bodies of carbonaceous chondrites and asteroid Ryugu.

Li Y, Kurokawa H, Sekine Y, Kebukawa Y, Nakano Y, Kitadai N Sci Adv. 2023; 9(50):eadh7845.

PMID: 38100590 PMC: 10848742. DOI: 10.1126/sciadv.adh7845.

References

Koga T, Naraoka H . A new family of extraterrestrial amino acids in the Murchison meteorite. Sci Rep. 2017; 7(1):636. PMC: 5428853. DOI: 10.1038/s41598-017-00693-9. View

Yanagawa H, Kobayashi Y, EGAMI F . Genesis of amino acids in the primeval sea. Formation of amino acids from sugars and ammonia in a modified sea medium. J Biochem. 1980; 87(1):359-62. DOI: 10.1093/oxfordjournals.jbchem.a132748. View

Lancet M, Anders E . Carbon isotope fractionation in the Fischer-tropsch synthesis and in meteorites. Science. 1970; 170(3961):980-2. DOI: 10.1126/science.170.3961.980. View

Furukawa Y, Horiuchi M, Kakegawa T . Selective stabilization of ribose by borate. Orig Life Evol Biosph. 2013; 43(4-5):353-61. DOI: 10.1007/s11084-013-9350-5. View

Smith K, House C, Arevalo Jr R, Dworkin J, Callahan M . Organometallic compounds as carriers of extraterrestrial cyanide in primitive meteorites. Nat Commun. 2019; 10(1):2777. PMC: 6592946. DOI: 10.1038/s41467-019-10866-x. View

Furukawa Y, Chikaraishi Y, Ohkouchi N, Ogawa N, Glavin D, Dworkin J . Extraterrestrial ribose and other sugars in primitive meteorites. Proc Natl Acad Sci U S A. 2019; 116(49):24440-24445. PMC: 6900709. DOI: 10.1073/pnas.1907169116. View

Oba Y, Takano Y, Naraoka H, Watanabe N, Kouchi A . Nucleobase synthesis in interstellar ices. Nat Commun. 2019; 10(1):4413. PMC: 6764953. DOI: 10.1038/s41467-019-12404-1. View

Nakamura-Messenger K, Messenger S, Keller L, Clemett S, Zolensky M . Organic globules in the Tagish Lake meteorite: remnants of the protosolar disk. Science. 2006; 314(5804):1439-42. DOI: 10.1126/science.1132175. View

Dworkin J, Deamer D, Sandford S, Allamandola L . Self-assembling amphiphilic molecules: Synthesis in simulated interstellar/precometary ices. Proc Natl Acad Sci U S A. 2001; 98(3):815-9. PMC: 14665. DOI: 10.1073/pnas.98.3.815. View

10.

Meinert C, Myrgorodska I, de Marcellus P, Buhse T, Nahon L, Hoffmann S . Ribose and related sugars from ultraviolet irradiation of interstellar ice analogs. Science. 2016; 352(6282):208-12. DOI: 10.1126/science.aad8137. View

11.

Yuen G, Blair N, Des Marais D, Chang S . Carbon isotope composition of low molecular weight hydrocarbons and monocarboxylic acids from Murchison meteorite. Nature. 1984; 307(5948):252-4. DOI: 10.1038/307252a0. View

12.

Tielens A, Charnley S . Circumstellar and interstellar synthesis of organic molecules. Orig Life Evol Biosph. 1997; 27(1-3):23-51. View

13.

Kim H, Ricardo A, Illangkoon H, Kim M, Carrigan M, Frye F . Synthesis of carbohydrates in mineral-guided prebiotic cycles. J Am Chem Soc. 2011; 133(24):9457-68. DOI: 10.1021/ja201769f. View

14.

Epstein S, Krishnamurthy R, Cronin J, Pizzarello S, Yuen G . Unusual stable isotope ratios in amino acid and carboxylic acid extracts from the Murchison meteorite. Nature. 1987; 326(6112):477-9. DOI: 10.1038/326477a0. View

15.

Messenger S . Identification of molecular-cloud material in interplanetary dust particles. Nature. 2000; 404(6781):968-71. DOI: 10.1038/35010053. View

16.

Sephton M, Watson J, Meredith W, Love G, Gilmour I, Snape C . Multiple Cosmic Sources for Meteorite Macromolecules?. Astrobiology. 2015; 15(10):779-86. PMC: 4623988. DOI: 10.1089/ast.2015.1331. View

17.

Cody G, Heying E, Alexander C, Nittler L, Kilcoyne A, Sandford S . Establishing a molecular relationship between chondritic and cometary organic solids. Proc Natl Acad Sci U S A. 2011; 108(48):19171-6. PMC: 3228457. DOI: 10.1073/pnas.1015913108. View

18.

Cooper G, Rios A . Enantiomer excesses of rare and common sugar derivatives in carbonaceous meteorites. Proc Natl Acad Sci U S A. 2016; 113(24):E3322-31. PMC: 4914185. DOI: 10.1073/pnas.1603030113. View

19.

Aponte J, Whitaker D, Powner M, Elsila J, Dworkin J . Analyses of Aliphatic Aldehydes and Ketones in Carbonaceous Chondrites. ACS Earth Space Chem. 2020; 3(3):463-472. PMC: 7330996. DOI: 10.1021/acsearthspacechem.9b00006. View

20.

Simkus D, Aponte J, Hilts R, Elsila J, Herd C . Compound-Specific Carbon Isotope Compositions of Aldehydes and Ketones in the Murchison Meteorite. Meteorit Planet Sci. 2020; 54(1):142-156. PMC: 7241578. DOI: 10.1111/maps.13202. View