Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer

Overview

Journal In Vivo

Specialty Oncology

Date 2021 Apr 29

PMID 33910854

Citations 4

Authors

Junki Harada

Yasuyoshi Miyata

Kyohei Araki

Tsuyoshi Matsuda

Yoshiaki Nagashima

Yuta Mukae

Kensuke Mitsunari

Tomohiro Matsuo

Kojiro Ohba

Yasushi Mochizuki

Hideki Sakai

Affiliations

Soon will be listed here.

Abstract

Background/aim: The pathological significance of thrombospondin (TSP)-1 and -2 in bladder cancer (BC) is well-known whereas that of TSP-3, 4 and 5 remains unclear. Our aim is to clarify the pathological significance and prognostic roles of TSP-3 to 5 expression in BC patients.

Patients And Methods: TSP-3 to 5 expression, proliferation index (PI), apoptotic index (AI) and microvessel density (MVD) were evaluated in 206 BC patients by immunohistochemical techniques.

Results: TSP-5 expression was positively associated with grade, T stage, metastasis, and worse prognosis. PI in TSP-5-positive tissues was significantly higher compared to negative tissues. In contrast, AI in TSP-5-positive tissues was significantly lower compared to negative tissues. Expressions of TSP-3 and 4 were not associated with any clinicopathological features, survival, PI, or AI.

Conclusion: TSP-5 plays important roles in malignant behavior via cell survival regulation whereas the pathological significance of TSP-3 and TSP-4 in BC might be minimal.

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