Targeting T Follicular Helper Cells to Control Humoral Allogeneic Immunity

Overview

Journal Transplantation

Specialty General Surgery

Date 2021 Apr 28

PMID 33909968

Citations 11

Authors

Kevin Louis

Camila Macedo

Diana Metes

Affiliations

Soon will be listed here.

Abstract

Humoral allogeneic immunity driven by anti-HLA donor-specific antibodies and antibody-mediated rejection (AMR) significantly impede prolonged survival of organ allografts after transplantation. Although the importance of T follicular helper (TFH) cells in controlling antibody responses has been long established, their role in directing donor-specific antibody generation leading to AMR was only recently appreciated in the clinical setting of organ transplantation. In this review, we provide a comprehensive summary of the current knowledge on the biology of human TFH cells as well as their circulating counterparts and describe their pivotal role in driving humoral alloimmunity. In addition, we discuss the intrinsic effects of current induction therapies and maintenance immunosuppressive drugs as well as of biotherapies on TFH cells and provide future directions and novel opportunities of biotherapeutic targeting of TFH cells that have the potential of bringing the prophylactic and curative treatments of AMR toward personalized and precision medicine.

Citing Articles

Activation and Regulation of Indirect Alloresponses in Transplanted Patients With Donor Specific Antibodies and Chronic Rejection.

Basu S, Dudreuilh C, Shah S, Sanchez-Fueyo A, Lombardi G, Dorling A Transpl Int. 2024; 37:13196.

PMID: 39228658 PMC: 11368725. DOI: 10.3389/ti.2024.13196.

Exploring Costimulatory Blockade-Based Immunologic Strategies in Transplantation: Are They a Promising Immunomodulatory Approach for Organ and Vascularized Composite Allotransplantation?.

Grosu-Bularda A, Hodea F, Zamfirescu D, Stoian A, Teodoreanu R, Lascar I J Pers Med. 2024; 14(3).

PMID: 38541064 PMC: 10971463. DOI: 10.3390/jpm14030322.

T follicular helper cells expansion in transplant recipients correlates with graft infiltration and adverse outcomes.

Desy O, Beland S, Thivierge M, Marcoux M, Desgagnes J, Bouchard-Boivin F Front Immunol. 2024; 15:1275933.

PMID: 38384450 PMC: 10879567. DOI: 10.3389/fimmu.2024.1275933.

Targeting T cells is a novel approach for donor-specific antibody desensitization of allograft candidates: an and study.

Ma N, Wu W, Zhao X, Xu L, Zhang X, Wang Y Haematologica. 2023; 109(4):1233-1246.

PMID: 37822236 PMC: 10985458. DOI: 10.3324/haematol.2023.283698.

Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation.

Zeng S, Crichton E, Ford M, Badell I Am J Transplant. 2023; 23(10):1511-1525.

PMID: 37302575 PMC: 11228286. DOI: 10.1016/j.ajt.2023.06.006.

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